Kynurenic acid
|
Basic information |
| Metabolite name | Kynurenic acid |
 | HMDB0000715 |
 |
C01717 |
 |
3845 |
| Synonyms | NA |
| No. of studies | 55 |
|
Basic information |
| Metabolite name | Kynurenic acid |
| HMDB0000715 |
|
C01717 |
|
3845 |
| Synonyms | NA |
| No. of studies | 55 |
|
Relationship between Kynurenic acid and depression (count: 55) |
| Study | Study Type  |
Comparison groups | Tissue | Organism | Up/Down regulated |
| Study M007 | Type1 | CRS group vs. control group | Urine | Wistar rat | Down |
| Study M008 | Type1 | CUMS group vs. control group | Urine | Sprague-Dawley rat | Up |
| Study M012 | Type1 | CVS group vs. control group | Urine | Wistar rat | Down |
| Study M012 | Type2 | CVS + fluoxetine group vs. CVS group | Urine | Wistar rat | Up |
| Study M012 | Type2 | CVS + CSGS group vs. CVS group | Urine | Wistar rat | Up |
| Study M024 | Type1 | CUMS group vs. control group | Urine | Sprague-Dawley rat | Up |
| Study M024 | Type2 | CUMS + fluoxetine group vs. CUMS group | Urine | Sprague-Dawley rat | Down |
| Study M026 | Type1 | CUMS group vs. control group | Urine | Wistar rat | Up |
| Study M027 | Type1 | CUMS group vs. control group | Urine | Wistar rat | Up |
| Study M027 | Type2 | CUMS + CSGS group vs. CUMS group | Urine | Wistar rat | Down |
| Study M027 | Type2 | CUMS + QZ group vs. CUMS group | Urine | Wistar rat | Down |
| Study M046 | Type1 | LPS group vs. control group | Nucleus accumbens | C57BL/6N mouse | Up |
| Study M046 | Type1 | LPS group vs. control group | Central amygdala | C57BL/6N mouse | Up |
| Study M053 | Type1 | CUMS group vs. control group | Urine | Wistar rat | Down |
| Study M053 | Type2 | CUMS + CSGS group vs. CUMS group | Urine | Wistar rat | Up |
| Study M068 | Type1 | CUMS group vs. control group | Urine | Sprague-Dawley rat | Down |
| Study M068 | Type2 | CUMS + citalopram group vs. CUMS group | Urine | Sprague-Dawley rat | Up |
| Study M079 | Type1 | acute LPS group vs. control group | Hippocampus | Sprague-Dawley rat | Down |
| Study M082 | Type3 | medium dose of DG group vs. control group | Hippocampus | C57BL/6J mouse | Up |
| Study M089 | Type3 | fluoxetine vs. control group | Plasma | Rhesus monkey | Up |
| Study M096 | Type1 | CUMS group vs. control group | Prefrontal cortex | Wistar rat | Down |
| Study M096 | Type1 | CUMS group vs. control group | Plasma | Wistar rat | Down |
| Study M096 | Type2 | CUMS + paroxetine group vs. CUMS group | Prefrontal cortex | Wistar rat | Up |
| Study M096 | Type2 | CUMS + paroxetine group vs. CUMS group | Plasma | Wistar rat | Up |
| Study M1013 | Type1 | MDD group vs. control group | Serum | Human | Down |
| Study M1030 | Type1 | MDD group vs. control group | Plasma | Human | Down |
| Study M1034 | Type1 | small intestinal bacterial overgrowth and chronic constipation group vs. control group | Urine | Human | Down |
| Study M1036 | Type2 | IBS-D with low-tryptophan and FODMAP diet subgroup, after diet intervention vs. baseline | Urine | Human | Up |
| Study M1059 | Type1 | CRS group vs. control group | Cecum | Wistar rat | Up |
| Study M1059 | Type1 | CRS group vs. control group | Hippocampus | Wistar rat | Down |
| Study M1059 | Type1 | CRS group vs. control group | Hypothalamus | Wistar rat | Down |
| Study M1059 | Type1 | CRS group vs. control group | Colon | Wistar rat | Up |
| Study M1059 | Type1 | CRS group vs. control group | Serum | Wistar rat | Up |
| Study M1059 | Type1 | CRS group vs. control group | Cortex | Wistar rat | Down |
| Study M1105 | Type1 | psychological stress group vs. control group | Faece | C57BL/6 J mouse | Down |
| Study M1107 | Type1 | CRS group vs. control group | Prefrontal cortex | C57/6 J mouse | Down |
| Study M1108 | Type2 | CRS + Roseburia Intestinalis. group vs. CRS group | Prefrontal cortex | C57/6 J mouse | Up |
| Study M1139 | Type1 | depression group vs. control group | Plasma | Human | Down |
| Study M470 | Type1 | rMDD group vs. control group | Plasma | Human | Down |
| Study M489 | Type1 | depression group vs. control group | Serum | Human | Down |
| Study M492 | Type1 | ACTH group vs. control group | Urine | Wistar rat | Down |
| Study M492 | Type2 | ACTH + CGA group vs. ACTH group | Urine | Wistar rat | Up |
| Study M492 | Type2 | ACTH + memantine group vs. ACTH group | Urine | Wistar rat | Up |
| Study M493 | Type1 | depression group vs. control group | Serum | Human | Down |
| Study M493 | Type4 | ketamine responder group vs. non-responder group at 24 h and 13 d | Serum | Human | Up |
| Study M513 | Type1 | female MDD group vs. female HC group | Serum | Human | Down |
| Study M513 | Type1 | male MDD group vs. male HC group | Serum | Human | Down |
| Study M516 | Type1 | SMG-treated group vs. control group | Urine | Sprague-Dawley rat | Up |
| Study M518 | Type1 | depression group vs. control group | Plasma | Human | Down |
| Study M524 | Type1 | hydrocortisone group vs. control group | Plasma | Sprague-Dawley rat | Down |
| Study M524 | Type2 | hydrocortisone + Tiansi Liquid group vs. hydrocortisone group | Plasma | Sprague-Dawley rat | Up |
| Study M525 | Type1 | CSDS group vs. control group | Hippocampus | C57BL/6 mouse | Down |
| Study M540 | Type1 | CUMS group vs. control group | Hippocampus | Sprague-Dawley rat | Up |
| Study M570 | Type1 | CMS group vs. control group | Serum | BALB/c mouse | Down |
| Study M596 | Type1 | elderly depression group vs. elderly control group | Urine | Human | Up |
| Study M602 | Type1 | MDD group vs. control group | Plasma | Human | Down |
| Study M602 | Type4 | responder group vs. non-responder group | Plasma | Human | Down |
| Study M604 | Type1 | CUMS group vs. control group | Faece | Sprague-Dawley rat | Down |
| Study M604 | Type2 | CUMS + PBR group vs. CUMS group | Faece | Sprague-Dawley rat | Up |
| Study M608 | Type1 | CUMS group vs. control group | Faece | Sprague-Dawley rat | Down |
| Study M627 | Type1 | CUMS group vs. control group | Cortex | Sprague-Dawley rat | Down |
| Study M627 | Type1 | CUMS group vs. control group | Hippocampus | Sprague-Dawley rat | Down |
| Study M627 | Type1 | CUMS group vs. control group | Colon | Sprague-Dawley rat | Up |
| Study M633 | Type1 | corticosterone group vs. control group | Urine | C57BL/6 mouse | Down |
| Study M633 | Type2 | corticosterone + Chrysanthemum morifolium group vs. corticosterone group | Urine | C57BL/6 mouse | Up |
| Study M672 | Type1 | SMG group vs. control group | Urine | Sprague-Dawley rat | Up |
| Study M701 | Type1 | MDD group vs. control group | Plasma | Human | Down |
| Study M720 | Type1 | CUMS susceptible group vs. control group | Habenula | Sprague-Dawley rat | Down |
| Study M724 | Type1 | MDD group vs. control group | Serum | Human | Down |
| Study M732 | Type1 | CUMS + high dose of propionate group vs. CUMS group | Hippocampus | Sprague-Dawley rat | Unknown |
| Study M756 | Type1 | depression group vs. control group | Serum | Human | Down |
| Study M766 | Type1 | CUS group vs. control group | Faece | Sprague-Dawley rat | Down |
| Study M787 | Type1 | CRS group vs. control group | Colon | Wistar rat | Up |
| Study M793 | Type1 | current MDD group vs. control group | Plasma | Human | Down |
| Study M806 | Type1 | CUMS group vs. control group | Urine | C57BL/6 mouse | Down |
| Study M806 | Type2 | corticosterone + Gleditsiae spina group vs. corticosterone group | Urine | C57BL/6 mouse | Up |
| Study M879 | Type1 | unipolar depression group vs. control group | Plasma | Human | Down |
| Study M884 | Type1 | CSDS group vs. control group | Urine | C57BL/6J mouse | Up |
| Study M884 | Type1 | CSDS group vs. control group | Ileum | C57BL/6J mouse | Up |
| Study M884 | Type1 | CSDS group vs. control group | Colon | C57BL/6J mouse | Up |
| Study M884 | Type1 | CSDS group vs. control group | Faece | C57BL/6J mouse | Up |
| Study M912 | Type1 | CUMS group vs. control group | Serum | ICR mouse | Up |
| Study M920 | Type1 | anhedonia-susceptible group vs. control grou | Nucleus accumbens | Sprague-Dawley rat | Down |
| Study M976 | Type1 | small intestinal bacterial overgrowth group vs. control group | Urine | Human | Down |
| Study M982 | Type2 | adult MDD group, post-treatment vs. baseline | Plasma | Human | Up |