Study M1036
Study name | Chojnacki C 2023c |
Title | The usefulness of the Low-FODMAP diet with limited tryptophan intake in the treatment of diarrhea-predominant irritable bowel syndrome |
Overall design | The aim of this study was to evaluate the efficacy of a low-fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (low-FODMAP) diet with a concomitant reduction in tryptophan intake in irritable bowel syndrome with diarrhea predominance (IBS-D) in relation to its metabolism via the serotonin and kynurenine pathways. The study involved 40 healthy people (control group) and 80 patients with IBS-D (IBS-D group). IBS-D patients were randomly divided into two groups (Groups IIA and IIB). In Group IIA, the low-FODMAP diet was recommended for 8 weeks (IBS-D with FODMAP diet subgroup, n =40), while in Group IIB, the same diet was recommended but with limited tryptophan intake for 8 weeks (IBS-D with low-tryptophan and FODMAP diet subgroup, n =40). The concentrations of tryptophan and its metabolites in urine were determined using an LC-MS/MS method, before and after diet intervention. Depression levels were ameliorated by diet intervention in both subgroups. |
Study Type | Type1; Type2; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive symptom; Depressive symptom with comorbidity; Depressive symptom with comorbidity; |
Criteria for depression | Not reported |
Sample size | 120 |
Tissue | Peripheral; Urine; Urine; |
Platform | MS-based; LC-MS: not reported; |
PMID | |
DOI | |
Citation | Chojnacki C, Poplawski T, Blonska A, et al. The usefulness of the Low-FODMAP diet with limited tryptophan intake in the treatment of diarrhea-predominant irritable bowel syndrome. Nutrients. 2023 Apr 11;15(8):1837. |
Metabolite |
