Study M007
Study name | Zhang FX 2010 |
Title | Metabonomics study of urine and plasma in depression and excess fatigue rats by ultra fast liquid chromatography coupled with ion trap-time of flight mass spectrometry |
Overall design | In this study, a novel metabonomic method based on fast liquid chromatography coupled with ion trap-time of flight mass spectrometry (UFLC/MS-IT-TOF) was applied to study the metabolic changes of plasma and urine in depression rats. Rats were randomly separated into the following 2 groups (n = 11 in each group): (1) control group, (2) CRS group (chronic restraint stress). In brief, the rats in the CRS group were kept in a restraint box for 6 h every day (from 9:00 am to 15:00 pm) lasted 6 weeks. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Rat; Wistar rat; |
Categories of depression | Animal model; Chronic restraint stress model; Chronic restraint stress model; |
Criteria for depression | Tail suspension test |
Sample size | 22 |
Tissue | Peripheral; Blood; Plasma; Peripheral; Urine; Urine; |
Platform | MS-based; LC-MS: Ultra Fast Liquid Chromatography (UFLC) system with ESI-IT-TOFMS (Shimadzu, Kyoto, Japan); |
PMID | |
DOI | |
Citation | Zhang F, Jia Z, Gao P, et al. Metabonomics study of urine and plasma in depression and excess fatigue rats by ultra fast liquid chromatography coupled with ion trap-time of flight mass spectrometry. Mol Biosyst 2010;6(5):852-61. |
Metabolite | L-Leucine; Hippuric acid; Pantothenic acid; Methyl hippurate; Cholic acid; Chenodeoxycholic acid; LysoPC(16:0); L-leucyl-L-proline; Phytosphingosine; Spermine; Propionylcarnitine; Butyrylcarnitine; Ethyl N2-acetyl-L-argininate; |
