Study M524
Study name | Cheng D 2018 |
Title | Tiansi Liquid modulates gut microbiota composition and tryptophan-kynurenine metabolism in rats with hydrocortisone-induced depression |
Overall design | The authors examined the effect of Tiansi Liquid in a rat model of hydrocortisone-induced depression using behavioral testing, 16S rRNA high-throughput pyrosequencing and high-performance liquid chromatography-mass spectrometry-based metabolomics of the tryptophan (TRP)-kynurenine (KYN) pathway. A stress-induced depression model was established by intraperitoneally injecting hydrocortisone 40 mg/kg once a day for 21 consecutive days. Rats were divided into the following 3 groups (n = 10 in each group): (1) control group, (2) hydrocortisone group, (3) hydrocortisone + Tiansi Liquid group (hydrocortisone plus Tiansi Liquid treatment at the dose of 0.45 g/kg). Drugs were administered once per day during the model building period. |
Study Type | Type1; Type2; |
Data available | Unavailable |
Organism | Rat; Sprague-Dawley rat; |
Categories of depression | Animal model; Other animal model; Other animal model; |
Criteria for depression | Sucrose preference test |
Sample size | 30 |
Tissue | Peripheral; Blood; Plasma; |
Platform | MS-based; LC-MS: HPLC with SCIEX Ultimate 3000-API 3200 QTRAP TOF mass spectrometer (ABSCIEX, Boston, Massachusetts, USA); |
PMID | |
DOI | |
Citation | Cheng D, Chang H, Ma S, et al. Tiansi liquid modulates gut microbiota composition and tryptophan-kynurenine metabolism in rats with hydrocortisone-induced depression. Molecules. 2018 Oct 31;23(11). pii: E2832. |
Metabolite |
