Study M008
Study name | Zheng SN 2010 |
Title | Urinary metabonomic study on biochemical changes in chronic unpredictable mild stress model of depression |
Overall design | An animal model of depression was produced by chronic unpredictable mild stress (CUMS). Metabolic profiling of the urine was performed by using ultra performance liquid chromatography coupled to mass spectrometry (UPLC-MS). Rats were divided into 2 groups (n = 8 in each group): (1) control group, (2) CUMS group. The CUMS stress procedure lasted for 11 weeks. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Rat; Sprague-Dawley rat; |
Categories of depression | Animal model; Chronic mild stress model; Chronic mild stress model; |
Criteria for depression | Sucrose preference test |
Sample size | 16 |
Tissue | Peripheral; Urine; Urine; |
Platform | MS-based; LC-MS: Waters ACQUITY ultra performance liquid chromatography system coupled to a Micromass Quattro Micro API mass spectrometer (Waters Corp., Milford, MA); |
PMID | |
DOI | |
Citation | Zheng S, Yu M, Lu X, et al. Urinary metabonomic study on biochemical changes in chronic unpredictable mild stress model of depression. Clin Chim Acta 2010;411(3-4):204-9. |
Metabolite | Citric acid; L-Phenylalanine; L-Tryptophan; Hippuric acid; Kynurenic acid; N2-Succinyl-L-ornithine; |
