Study M627
Study name | Li CC 2020 |
Title | Peripheral and cerebral abnormalities of the tryptophan metabolism in the depression-like rats induced by chronic unpredicted mild stress |
Overall design | The aim of this study was to compare the difference between peripheral and cerebral tryptophan metabolism in depression. The chronic unpredicted mild stress (CUMS) was used to induce depressive-like syndrome in rats. Sprague-Dawley rats were divided into the following 2 groups: (1) control group, and (2) CUMS group. The CUMS stress procedure lasted for 5 weeks. Tryptophan metabolites in the cortex, hippocampus and colon were measured by prominence ultrafast liquid chromatography coupled with a QTRAP 5500 mass spectrometer (n = 10 per group). |
Study Type | Type1; |
Data available | Unavailable |
Organism | Rat; Sprague-Dawley rat; |
Categories of depression | Animal model; Chronic mild stress model; Chronic mild stress model; |
Criteria for depression | Sucrose preference test, forced swimming test |
Sample size | 20 |
Tissue | Peripheral; Gut; Colon; Central; Brain; Cortex; Central; Brain; Hippocampus; |
Platform | MS-based; LC-MS: prominence ultrafast liquid chromatography (UFLC) (Shimadzu, Kyoto, Japan) with QTRAP 5500 mass spectrometer (AB SCIEX, Framingham, MA, USA); |
PMID | |
DOI | |
Citation | Li CC, Jiang N, Gan L, et al. Peripheral and cerebral abnormalities of the tryptophan metabolism in the depression-like rats induced by chronic unpredicted mild stress. Neurochem Int. 2020;138:104771. |
Metabolite |
