Study M912
Study name | Qu YC 2022 |
Title | Gut microbiota-mediated elevated production of secondary bile acids in chronic unpredictable mild stress |
Overall design | The aim of this study was to explore potential gut microbiota-associated metabolites and the relationship between bile acid metabolic profiles and gut microbiota altered in chronic unpredictable mild stress (CUMS) progression. ICR mice were divided into the following 2 groups (n = 12 in each group): (1) control group, and (2) CUMS group. The CUMS stress procedure lasted for 8 weeks. Serum samples were collected for untargeted metabolomic analysis. The bile acid profiles in the serum, feces, and liver were quantified using UPLC-Q/Orbitrap-HRMS methods. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Mouse; ICR mouse; |
Categories of depression | Animal model; Chronic mild stress model; Chronic mild stress model; |
Criteria for depression | Sucrose preference test, forced swimming test, tail suspension test |
Sample size | 24 |
Tissue | Peripheral; Liver; Liver; Peripheral; Blood; Serum; Peripheral; Faece; Faece; |
Platform | MS-based; LC-MS: Dionex Ultimate 3000 UPLC system with Q Exactive Orbitrap mass spectrometer (Thermo Fisher Scientific, USA); |
PMID | |
DOI | |
Citation | Qu Y, Su C, Zhao Q, et al. Gut microbiota-mediated elevated production of secondary bile acids in chronic unpredictable mild stress. Front Pharmacol. 2022 Mar 7;13:837543. |
Metabolite | Linoleic acid; Pyroglutamic acid; Glutaric acid; N-Acetyl-L-aspartic acid; L-Proline; L-Glutamic acid; L-Serine; L-Lactic acid; L-Aspartic acid; 5-Hydroxyindoleacetic acid; D-Fructose; L-Arginine; Uridine; Taurocholic acid; Chenodeoxycholic acid; Kynurenic acid; Xanthurenic acid; Indoleacetic acid; Oxoglutaric acid; Hydroxykynurenine; Fumaric acid; Pyruvic acid; Betaine; Gluconic acid; cis-Aconitic acid; Phenylethylamine; N-Acetylserotonin; 3-Phosphoglyceric acid; 5'-Methylthioadenosine; Nicotinamide ribotide; Taurodeoxycholic acid; S-Adenosylhomocysteine; Adenine; Nicotinic acid; 3,4-Dihydroxymandelic acid; Cytidine; Thymidine; Riboflavin; Deoxycholic acid; Butyric acid; Metanephrine; Carnosine; Ureidopropionic acid; 4-Hydroxyphenylpyruvic acid; L-Sorbose; 2-Ketobutyric acid; 13-HODE; Anserine; Glucaric acid; Stearidonic acid; Prostaglandin H2; L-Fucose; 5-Methylcytosine; 6-Keto-prostaglandin F1a; N-Formyl-L-methionine; Ergothioneine; Retinal; Vitamin A; Beta-D-Fructose 6-phosphate; Prostaglandin G2; 3-Methylindole; 5-HPETE; 13-L-Hydroperoxylinoleic acid; 2-Oxoarginine; Saccharopine; Lithocholyltaurine; Deoxycholylglycine; L-Arabinonate; 2-keto-3-deoxy-L-rhamnonate; Octopine; 12-KETE; 9(S)-HPODE; 12,13-DHOME; Traumatic acid; (2E,4Z,7Z,8E)-Colnelenic acid; Ursodeoxycholic acid; |
