Study M513
Study name | Zhou YL 2019 |
Title | Cross-sectional relationship between kynurenine pathway metabolites and cognitive function in major depressive disorder |
Overall design | The aim of this study was to examine the relationship between cognitive impairment and kynurenine pathway metabolites in patients with MDD. A total of 146 patients with MDD according to DSM-V (76 males and 70 females) and 72 healthy controls (HCs, 41 males and 31 females) were enrolled, and the severity of depressive symptoms using the 17-item Hamilton Depression Rating Scale (HAMD-17) and cognitive performance including speed of processing, working memory, visual learning and verbal learning were assessed. Blood samples were collected, and serum concentrations of tryptophan (TRP), kynurenine (KYN) and kynurenic acid (KYNA) were measured by liquid chromatography-tandem mass spectrometry. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Depression; Depression; |
Criteria for depression | DSM-V diagnosed MDD, HAMD-17 >= 17 |
Sample size | 218 |
Tissue | Peripheral; Blood; Serum; |
Platform | MS-based; LC-MS: Agilent 1200 series HPLC system with Agilent 6410 triple quadrupole mass spectrometer (Agilent Technologies, Inc., Santa Clara, CA, USA); |
PMID | |
DOI | |
Citation | Zhou Y, Zheng W, Liu W, et al. Cross-sectional relationship between kynurenine pathway metabolites and cognitive function in major depressive disorder. Psychoneuroendocrinology. 2019 Mar;101:72-79. |
Metabolite |
