Study M793
Study name | Milaneschi Y 2021 |
Title | The association between plasma tryptophan catabolites and depression: the role of symptom profiles and inflammation |
Overall design | The aim of this study was to examine the association of tryptophan catabolites levels with the presence of major depressive disorder (MDD), depressive symptom profiles, and inflammatory markers. Participants were from the Netherlands Study of Depression and Anxiety (NESDA). The analytical sample included 2495 subjects with measures of circulating tryptophan catabolites and categorized as follow: participants with current (current MDD group; within the past 6 month; n = 1100) and 753 with remitted MDD (remitted MDD group; lifetime but not current; n = 753), and healthy controls (control group; without any lifetime depressive/anxiety disorder; n = 642). Tryptophan catabolites were assessed by liquid chromatography tandem mass spectrometry. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Depression; Depression; |
Criteria for depression | DSM-IV diagnosed MDD |
Sample size | 1742 |
Tissue | Peripheral; Blood; Plasma; |
Platform | MS-based; LC-MS: UPLC with positive multiple-reaction monitoring on two mass spectrometry instruments (AB Sciex API 5000System); |
PMID | |
DOI | |
Citation | Milaneschi Y, Allers KA, Beekman ATF, et al. The association between plasma tryptophan catabolites and depression: the role of symptom profiles and inflammation. Brain Behav Immun. 2021 Jul 9:S0889-1591(21)00271-3. |
Metabolite |
