Study M701
Study name | Colle R 2020 |
Title | Peripheral tryptophan, serotonin, kynurenine, and their metabolites in major depression: a case-control study |
Overall design | The aim of this study was to extensively investigate plasma tryptophan levels and 10 metabolites of the serotonin and kynurenine pathways. A total of 173 patients suffering from a current major depressive episode (MDD group) and 214 healthy controls (control group) were recruited. Fasting plasma levels of peripheral metabolites, including tryptophan, serotonin, 5-hydroxytryptophan, 5-hydroxyindoleacetic acid, kynurenine, anthranilic acid, kynurenic acid, nicotinamide, picolinic acid, xanthurenic acid, and 3-hydroxyanthranilic acid, were quantified using ultra-performance liquid chromatography coupled with mass spectrometry. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Depression; Depression; |
Criteria for depression | Diagnosed MDD, HAMD-17 >= 18 |
Sample size | 387 |
Tissue | Peripheral; Blood; Plasma; |
Platform | MS-based; LC-MS: Waters Acquity UPLC system coupled to Thermo Scientific Q Exactive mass spectrometer; |
PMID | |
DOI | |
Citation | Colle R, Masson P, Verstuyft C, et al. Peripheral tryptophan, serotonin, kynurenine, and their metabolites in major depression: a case-control study. Psychiatry Clin Neurosci. 2020;74(2):112-117. |
Metabolite |
