Study M596
Study name | Chojnacki C 2020 |
Title | Tryptophan intake and metabolism in older adults with mood disorders |
Overall design | The aim of this study was to assess the intake and metabolism of tryptophan in elderly patients with mood disorders. Ninety subjects in three groups, 30 subjects each, were enrolled in this study: controls (healthy young adults, young control group) and elderly individuals without (elderly control group) or with (elderly depression group) symptoms of mild and moderate depression, as assessed by the Hamilton Depression Rating Scale (HAM-D) and further referred to as mood disorders. Urine samples for the analysis of tryptophan metabolites were collected in the morning. Using liquid chromatography with tandem mass spectrometry, the concentration of L-tryptophan and its following metabolites: 5-hydroxyindoleacetic acid, L-kynurenine, kynurenic acid, xanthurenic acid, and quinolinic acid, were determined. The levels of these metabolites were expressed in mg per gram of creatinine (mg/gCr). |
Study Type | Type1; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive symptom; Depressive symptom; Depressive symptom; |
Criteria for depression | Geriatric depressive symptom |
Sample size | 60 |
Tissue | Peripheral; Urine; Urine; |
Platform | MS-based; LC-MS: liquid chromatography with tandem mass spectrometry (LC-MS/MS, Ganzimmun Diagnostics AG, Mainz, Germany); |
PMID | |
DOI | |
Citation | Chojnacki C, Poplawski T, Chojnacki J, et al. Tryptophan intake and metabolism in older adults with mood disorders. Nutrients. 2020;12(10):3183. |
Metabolite |
