Study M976
Study name | Chojnacki C 2022a |
Title | Altered tryptophan metabolism on the kynurenine pathway in depressive patients with small intestinal bacterial overgrowth |
Overall design | The aim of this study was to evaluate selected metabolites of the tryptophan kynurenine pathway in depressive patients with small intestinal bacterial overgrowth. The study involved 40 healthy people (control group) and 40 patients with predominant small intestinal bacterial overgrowth (small intestinal bacterial overgrowth group). The concentrations of tryptophan, kynurenine, kynurenic acid, and quinolinic acid in urine were determined using an LC-MS/MS method, before and after cyclic treatment with an antibiotic drug, rifaximin, for three months. The mean HAMD scores for the small intestinal bacterial overgrowth group were 15.5 (before treatment) and 10.2 (after rifaximin treatment). |
Study Type | Type1; Type2; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive symptom; Depressive symptom with comorbidity; Depressive symptom with comorbidity; |
Criteria for depression | Not reported |
Sample size | 80 |
Tissue | Peripheral; Urine; Urine; |
Platform | MS-based; LC-MS: not reported; |
PMID | |
DOI | |
Citation | Chojnacki C, Konrad P, Blonska A, et al. Altered tryptophan metabolism on the kynurenine pathway in depressive patients with small intestinal bacterial overgrowth. Nutrients. 2022 Aug 6;14(15):3217. |
Metabolite | L-Tryptophan; L-Kynurenine; Kynurenic acid; Quinolinic acid; Kynurenine/Tryptophan ratio; |
