Study M518
Study name | Liu HY 2018 |
Title | The metabolic factor kynurenic acid of kynurenine pathway predicts major depressive disorder |
Overall design | This study aimed to explore a novel diagnostic method analyzing peripheral blood with mass spectrometry to assess metabolites from kynurenine pathway in patients with MDD and Bipolar Depression (BD). Thirty-three patients with MDD (depression group), 20 patients with BD, and 23 healthy control (control group) participants were enrolled. Metabolic factors of kynurenine pathway from plasma including tryptophan, kynurenine, kynurenic acid, and quinolinic acid were analyzed by UPLC-3Q-MS, and levels compared across three groups. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Depression; Depression; |
Criteria for depression | DSM-V diagnosed MDD, HAMD-24 >= 20 |
Sample size | 56 |
Tissue | Peripheral; Blood; Plasma; |
Platform | MS-based; LC-MS: ultra-performance liquid chromatography machine (ACQUITY UPLC; Waters, Milford, MA, USA) with SCIEX SelexION Triple QuadTM 5500 System (Applied Biosystems, AB SCIEX, Foster City, CA, USA); |
PMID | |
DOI | |
Citation | Liu H, Ding L, Zhang H, et al. The metabolic factor kynurenic acid of kynurenine pathway predicts major depressive disorder. Front Psychiatry. 2018 Nov 19;9:552. |
Metabolite | Kynurenic acid; |
