Study M525
Study name | Xu K 2019 |
Title | Validation of the targeted metabolomic pathway in the hippocampus and comparative analysis with the prefrontal cortex of social defeat model mice |
Overall design | Aiming to further investigate the mechanisms of MDD, liquid chromatography-tandem mass spectrometry was employed to measure target metabolites in the hippocampus of chronic social defeat stress model mice. Mice were divided into the following 2 groups: (1) control group, (2) CSDS group. CSDS-treated mice with an social interaction (SI) ratio < 1 were considered stress-susceptible, while the remaining mice with SI ratio > 1 were considered stress-resilient. 10 samples per group were used for metabonomic analysis. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Mouse; C57BL/6 mouse; |
Categories of depression | Animal model; Social defeat model; Social defeat model; |
Criteria for depression | Social interaction test, sucrose preference test |
Sample size | 30 |
Tissue | Central; Brain; Hippocampus; |
Platform | MS-based; LC-MS: Waters HPLC with AB Sciex Triple QuadTM6500 MS system; |
PMID | |
DOI | |
Citation | Xu K, He Y, Chen X, et al. Validation of the targeted metabolomic pathway in the hippocampus and comparative analysis with the prefrontal cortex of social defeat model mice. J Neurochem. 2019 Jun;149(6):799-810. |
Metabolite |
