Study M879
Study name | Ryan KM 2020b |
Title | Tryptophan metabolite concentrations in depressed patients before and after electroconvulsive therapy |
Overall design | The aim of this study was to investigate plasma concentrations of kynurenine pathway metabolites in medicated patients with depression (n = 94) compared to age- and sex-matched healthy controls (control group, n = 57), and in patients with depression after electroconvulsive therapy (ECT) in a real-world clinical setting. The depression group included patients with unipolar depression (unipolar depression group, n = 73) and bipolar depression (bipolar depression group, n = 21). ECT was administered twice-weekly with hand-held electrodes. LC/MS was used to quantify circulating concentrations of tryptophan, kynurenine, quinolinic acid, kynurenic acid, 3-hydrokynurenine, anthranilic acid, xanthurenic acid, 3-hydroxyanthranilic acid, and picolinic acid. |
Study Type | Type1; Type2; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Depression; Depression; |
Criteria for depression | DSM-IV diagnosed MDD, HAMD-24 >= 21 |
Sample size | 130 |
Tissue | Peripheral; Blood; Plasma; |
Platform | MS-based; LC-MS: not reported; |
PMID | |
DOI | |
Citation | Ryan KM, Allers KA, McLoughlin DM, et al. Tryptophan metabolite concentrations in depressed patients before and after electroconvulsive therapy. Brain Behav Immun. 2020 Jan;83:153-162. |
Metabolite | L-Tryptophan; L-Kynurenine; Kynurenic acid; Xanthurenic acid; Hydroxykynurenine; 3-Hydroxyanthranilic acid; Kynurenic acid/Kynurenine ratio; |
