Study M493
Study name | Zhou YL 2018 |
Title | Antidepressant effect of repeated ketamine administration on kynurenine pathway metabolites in patients with unipolar and bipolar depression |
Overall design | The aims of this study were to examine whether kynurenine pathway metabolites were altered by six infusions of ketamine and whether these biological factors could act as potential biomarkers to predict ketamine's antidepressant effects. Six intravenous infusions of ketamine (0.5mg/kg) were administered to 84 patients with unipolar and bipolar depression over a 12-d period. Symptom severity and response were assessed using the Montgomery-Asberg Scale (MADRS), and blood samples were collected at baseline and 24h following the first infusion and at 24h and 14d after the sixth infusion (24h, 13d and 26d). Blood samples from sixty healthy controls were collected for comparison with samples from the patients. Serum concentrations of tryptophan (TRP), kynurenine (KYN) and kynurenic acid (KYNA) were measured by the liquid chromatography-tandem mass spectrometry method. |
Study Type | Type1; Type4; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Treatment-resistant depression; Treatment-resistant depression; |
Criteria for depression | DSM-V diagnosed MDD, HAMD-17 >= 17 |
Sample size | 144 |
Tissue | Peripheral; Blood; Serum; |
Platform | MS-based; LC-MS: Agilent 1200 series HPLC system (Agilent Technologies, Inc., Santa Clara, CA,USA) with Agilent 6410 triple quadrupole mass spectrometer; |
PMID | |
DOI | |
Citation | Zhou Y, Zheng W, Liu W, et al. Antidepressant effect of repeated ketamine administration on kynurenine pathway metabolites in patients with unipolar and bipolar depression. Brain Behav Immun. 2018. pii: S0889-1591(18)30307-6. |
Metabolite |
