Study M089
Study name | Su SY 2016 |
Title | Peripheral fibroblast metabolic pathway alterations in juvenile rhesus monkeys undergoing long-term fluoxetine administration |
Overall design | The authors reported on biochemical pathways perturbed upon chronic fluoxetine administration to juvenile macaques using LC-MS-based global metabolomics analyses of fibroblasts plasma, and cerebrospinal fluid (CSF). All the animals were divided into 2 groups (n = 8 in each group): (1) control group and (2) fluoxetine group. Animals were treated daily with oral fluoxetine or vehicle for one year. Dosing was initiated at 1 year of age at 1.6 mg/kg/d and adjusted to 2.4 mg/kg/d after 11 months. |
Study Type | Type3; |
Data available | Unavailable |
Organism | Non-human primate; Rhesus monkey; |
Categories of depression | Healthy individuals; Healthy individuals; Healthy individuals; |
Criteria for depression | Not reported |
Sample size | 16 |
Tissue | Peripheral; Fibroblast; Fibroblast; Peripheral; Blood; Plasma; Central; Cerebrospinal fluid; Cerebrospinal fluid; |
Platform | MS-based; LC-MS: Prominence UFLC high performance liquid chromatography system (Shimadzu, Columbia, MD, USA) with 5500 QTRAP triple quadrupole mass spectrometer (AB/SCIEX, Framingham, MA, USA); |
PMID | |
DOI | |
Citation | Su SY, Hogrefe-Phi CE, Asara JM, et al. Peripheral fibroblast metabolic pathway alterations in juvenile rhesus monkeys undergoing long-term fluoxetine administration. Eur Neuropsychopharmacol 2016;26(7):1110-8. |
Metabolite | Kynurenic acid; Xanthine; Acetoacetic acid; Aminoadipic acid; |
