Study M884
Study name | Zheng X 2019 |
Title | Kynurenic acid/GPR35 axis restricts NLRP3 inflammasome activation and exacerbates colitis in mice with social stress |
Overall design | The aim of this study was to profile the change of tryptophan-kynurenine pathway in the chronic social defeat stress (CSDS) model. C57BL/6J mice were divided into the following 2 groups: (1) control group, and (2) CSDS group. C57BL/6J mice were exposed to a different CD-1 aggressor mouse each day for 10 min for 10 consecutive days. A targeted metabolomic analysis of tryptophan-kynurenine pathway was performed in the intestinal/colonic tissue, feces, urine and sera of mice (n = 6-8). |
Study Type | Type1; |
Data available | Unavailable |
Organism | Mouse; C57BL/6J mouse; |
Categories of depression | Animal model; Social defeat model; Social defeat model; |
Criteria for depression | Not reported |
Sample size | 14 |
Tissue | Peripheral; Gut; Ileum; Peripheral; Faece; Faece; Peripheral; Urine; Urine; Peripheral; Gut; Colon; |
Platform | MS-based; LC-MS: LC with API 4000+ triple quadrupole mass spectrometer (ABSCIEX, USA); |
PMID | |
DOI | |
Citation | Zheng X, Hu M, Zang X, et al. Kynurenic acid/GPR35 axis restricts NLRP3 inflammasome activation and exacerbates colitis in mice with social stress. Brain Behav Immun. 2019 Jul;79:244-255. |
Metabolite |
