Study M633
Study name | Liu T 2020a |
Title | A metabolomic study on the anti-depressive effects of two active components from Chrysanthemum morifolium |
Overall design | The aim of this study was to clarify the role of Chrysanthemum morifolium in ameliorating depression-like behaviour induced by corticosterone. C57BL/6 mice were divided into the following 4 groups (n = 8 in each group): (1) control group, (2) corticosterone group (corticosterone injection at the dose of 20 mg/kg), (3) corticosterone + fluoxetine group (corticosterone injection plus fluoxetine treatment at the dose of 5 mg/kg), and (4) corticosterone + Chrysanthemum morifolium group (corticosterone injection plus Chrysanthemum morifolium treatment at the dose of 3.33 g/kg). Drugs were administered via intragastric once per day once a day for 21 days. |
Study Type | Type1; Type2; |
Data available | Unavailable |
Organism | Mouse; C57BL/6 mouse; |
Categories of depression | Animal model; Other animal model; Other animal model; |
Criteria for depression | Sucrose preference test |
Sample size | 32 |
Tissue | Peripheral; Urine; Urine; |
Platform | MS-based; LC-MS: UltraPerformance Liquid Chromatography (UPLC) system (Dionex; UltiMate 3000 System, Thermo Scientific, USA) with Q/TOF mass spectrometer system; |
PMID | |
DOI | |
Citation | Liu T, Zhou N, Xu R, et al. A metabolomic study on the anti-depressive effects of two active components from Chrysanthemum morifolium. Artif Cells Nanomed Biotechnol. 2020;48(1):718-727. |
Metabolite | Citric acid; Pyroglutamic acid; Methylimidazoleacetic acid; N-Acetyl-L-aspartic acid; L-Isoleucine; L-Asparagine; L-Glutamine; Hippuric acid; Succinic acid; Uridine; L-leucyl-L-proline; Phytosphingosine; Kynurenic acid; Phenylacetylglycine; Xanthurenic acid; Creatinine; Oxoglutaric acid; Indoxyl sulfate; Uric acid; Taurine; Uracil; Creatine; cis-Aconitic acid; 5'-Methylthioadenosine; L-Malic acid; 2-Isopropylmalic acid; 2-Hydroxyglutarate; 5-Aminopentanoic acid; Caprylic acid; Allantoin; 3-Methyldioxyindole; p-Cresol sulfate; Guanidoacetic acid; Glycerylphosphorylethanolamine; Cortisol; Citraconic acid; Galactonic acid; Proline betaine; N-Methylhydantoin; Gulonic acid; Phenol sulphate; 4-Ethylphenylsulfate; Hexanoylglycine; 5-Methoxyindoleacetate; Mannitol; Thiamine; 5-Hydroxy-L-tryptophan; Nicotinuric acid; Sphinganine; N-Heptanoylglycine; Urocanic acid; Ketoleucine; N-Acetyl-L-phenylalanine; 4-O-Methylmelleolide; Sulfate; 1-Methylhistamine; 5-Amino-2-oxopentanoic acid; Trigonelline/Methyl nicotinate; N1-Methyl-2-pyridone-5-carboxamide; Allysine; Phosphohydroxypyruvic acid; Dopaquinone; 3-Dehydrocarnitine; 1-Methylguanosine; Hexanethioic acid S-propyl ester; Thiosulfate; Glutarate semialdehyde; DL-Glutamate; Homovanillin; N-Formyl-L-methionine; L-2-Amino-3-oxobutanoic acid; 5-L-Glutamyl-taurine; 3-Hydroxy-L-proline; Ethylmalonic acid; 2-Methylbutyrylglycine; |
