Study M470
Study name | Doolin K 2018 |
Title | Altered tryptophan catabolite concentrations in major depressive disorder and associated changes in hippocampal subfield volumes |
Overall design | This study examined circulating concentrations of C-reactive protein, plasma tryptophan, kynurenine (KYN), kynurenic acid (KYNA) and quinolinic acid (QUIN) and whole blood mRNA expression of indolamine 2,3 dioxygenase (IDO) in patients with major depressive disorder (MDD) compared with healthy controls (HC). A diagnosis of major depression was made according to DSM-IV. Depression severity was assessed using the Hamilton depression (HAM-D) rating scale. 74 MDD patients (MDD group), 39 with a first presentation of MDD (fpMDD group) and 35 with chronic or recurrent episodes (rMDD group), and 37 HC (control group) were recruited to the study. Whole blood and plasma samples were collected. Expression of markers in whole blood were measured by PCR, circulating CRP by ELISA and KP metabolites by LC-MS/MS. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Depression; Depression; |
Criteria for depression | DSM-IV diagnosed MDD, HAMD-17 > 17 |
Sample size | 111 |
Tissue | Peripheral; Blood; Plasma; |
Platform | MS-based; LC-MS: not reported; |
PMID | |
DOI | |
Citation | Doolin K, Allers KA, Pleiner S, et al. Altered tryptophan catabolite concentrations in major depressive disorder and associated changes in hippocampal subfield volumes. Psychoneuroendocrinology. 2018;95:8-17. |
Metabolite | L-Tryptophan; Kynurenic acid; Quinolinic acid; Kynurenine/Tryptophan ratio; |
