Study M720
Study name | Tian Y 2020 |
Title | Alterations of neurotransmitters and related metabolites in the habenula from CUMS-susceptible and -resilient rats |
Overall design | In this study, chronic unpredictable mild stress (CUMS) model was established in rats, susceptible group and resilient group were distinguished according to depressive-like behaviors. Sprague-Dawley rats were divided into the following 3 groups: (1) control group, (2) CUMS susceptible group, and (3) CUMS resilient group. The CUMS stress procedure lasted for 4 weeks. Multiple neurotransmitters and related metabolites in three metabolic pathways were determined by liquid chromatography-tandem mass spectrometry analysis, including tryptophanic pathway, GABAergic pathway and catecholaminergic pathway. Six habenula samples per group were used for metabonomic analysis. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Rat; Sprague-Dawley rat; |
Categories of depression | Animal model; Chronic mild stress model; Chronic mild stress model; |
Criteria for depression | Sucrose preference test, forced swimming test |
Sample size | 18 |
Tissue | Central; Brain; Habenula; |
Platform | MS-based; LC-MS: not reported; |
PMID | |
DOI | |
Citation | Tian Y, Wu Z, Wang Y, et al. Alterations of neurotransmitters and related metabolites in the habenula from CUMS-susceptible and -resilient rats. Biochem Biophys Res Commun. 2020;S0006-291X(20)32109-4. |
Metabolite | Gamma-Aminobutyric acid; L-Phenylalanine; L-Tryptophan; L-Glutamic acid; L-Glutamine; L-Aspartic acid; Succinic acid; 5-Hydroxyindoleacetic acid; |
