Study M920
Study name | Li Y 2022 |
Title | Neurotransmitter and related metabolic profiling in the nucleus accumbens of chronic unpredictable mild stress-induced anhedonia-like rats |
Overall design | The aim of this study was to investigate changes in neurotransmitters and their related metabolites in GABAergic, serotonergic and catecholaminergic pathways in the nucleus accumbens of a rat model of chronic unpredictable mild stress- (CUMS-) induced anhedonia-like behavior. Sprague-Dawley rats were divided into the following 2 groups: (1) control group, and (2) CUMS group. The CUMS stress procedure lasted for 5 weeks. After stress, 10 rats in the CUMS group showed more than 5% reduction in sucrose preference and were defined as anhedonia-susceptible (anhedonia-susceptible group), while the six rats in the CUMS group were designated as anhedonia-resilient (anhedonia-resilient group). Then, liquid chromatography-tandem mass spectrometry (LC-MS/MS) was employed to detect target neurotransmitters and related metabolites in the nucleus accumbens (n = 6/group). |
Study Type | Type1; |
Data available | Unavailable |
Organism | Rat; Sprague-Dawley rat; |
Categories of depression | Animal model; Chronic mild stress model; Chronic mild stress model; |
Criteria for depression | Sucrose preference test, forced swimming test |
Sample size | 18 |
Tissue | Central; Brain; Nucleus accumbens; |
Platform | MS-based; LC-MS: not reported; |
PMID | |
DOI | |
Citation | Li Y, Chen Z, Zhao J, et al. Neurotransmitter and related metabolic profiling in the nucleus accumbens of chronic unpredictable mild stress-induced anhedonia-like rats. Front Behav Neurosci. 2022 Apr 29;16:862683. |
Metabolite |
