Study M1034
Study name | Chojnacki C 2023a |
Title | Changes in tryptophan metabolism on serotonin and kynurenine pathways in patients with irritable bowel syndrome |
Overall design | The aim of this study was to evaluate the urinary excretion of selected tryptophan metabolites in patients with constipation-predominant and diarrhoea-predominant irritable bowel syndrome, related to somatic and mental symptoms. The study involved 40 healthy people (control group), 40 patients with small intestinal bacterial overgrowth and chronic diarrhea (small intestinal bacterial overgrowth and chronic diarrhea group), and 40 patients with small intestinal bacterial overgrowth and chronic constipation (small intestinal bacterial overgrowth and chronic constipation group). The concentrations of tryptophan and its metabolites in urine were determined using an LC-MS/MS method. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive symptom; Depressive symptom with comorbidity; Depressive symptom with comorbidity; |
Criteria for depression | Not reported |
Sample size | 120 |
Tissue | Peripheral; Urine; Urine; |
Platform | MS-based; LC-MS: not reported; |
PMID | |
DOI | |
Citation | Chojnacki C, Blonska A, Konrad P, et al. Changes in tryptophan metabolism on serotonin and kynurenine pathways in patients with irritable bowel syndrome. Nutrients. 2023 Mar 3;15(5):1262. |
Metabolite |
