Study M1139
Study name | Michal M 2023 |
Title | Tryptophan catabolites and depression in the general population: results from the Gutenberg Health Study |
Overall design | The aim of this study was to investigate the relationship of peripheral tryptophan catabolites with depression in a large population-based cohort. A total of 2040 participants without depression (control group, PHQ-9 < 5) and 248 participants with depression (depression group, PHQ-9 >= 10) were included. The tryptophan catabolites in the plasma were analyzed by a qualified LC-MS/MS. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive symptom; Depressive symptom; Depressive symptom; |
Criteria for depression | Patient Health Questionnaire-9 >= 10 |
Sample size | 2288 |
Tissue | Peripheral; Blood; Plasma; |
Platform | MS-based; LC-MS: Waters Acquity LC System with AB Sciex API 5000 System; |
PMID | |
DOI | |
Citation | Michal M, Schulz A, Wild PS, et al. Tryptophan catabolites and depression in the general population: results from the Gutenberg Health Study. BMC Psychiatry. 2023 Jan 11;23(1):27. |
Metabolite |
