Study M026
Study name | Jia HM 2013b |
Title | Integration of 1H NMR and UPLC-Q-TOF/MS for a comprehensive urinary metabonomics study on a rat model of depression induced by chronic unpredictable mild stress |
Overall design | Here, an integrated approach utilizing 1H NMR and UPLC-Q-TOF/MS together was firstly used for a comprehensive urinary metabonomics study on chronic unpredictable mild stress (CUMS) treated rats. Rats were divided into 2 groups (n = 8 in each group): (1) control group and (2) CUMS group. The CUMS stress procedure lasted for 4 weeks. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Rat; Wistar rat; |
Categories of depression | Animal model; Chronic mild stress model; Chronic mild stress model; |
Criteria for depression | Sucrose preference test |
Sample size | 16 |
Tissue | Peripheral; Urine; Urine; |
Platform | NMR; NMR: Bruker AV III 600 spectrometer (Bruker Biospin, Germany); MS-based; LC-MS: Waters Acquity Ultra Performance LC system with SYNAPT HDMS system (Waters Corporation, Milford, MA, USA); |
PMID | |
DOI | |
Citation | Jia HM, Feng YF, Liu YT, et al. Integration of 1H NMR and UPLC-Q-TOF/MS for a comprehensive urinary metabonomics study on a rat model of depression induced by chronic unpredictable mild stress. PLoS One 2013;8(5):e63624. |
Metabolite | 3-Hydroxybutyric acid; L-Phenylalanine; L-Valine; L-Leucine; L-Proline; L-Glutamic acid; L-Serine; L-Threonine; L-Isoleucine; L-Glutamine; Hippuric acid; L-Tyrosine; L-Kynurenine; Kynurenic acid; Hydroxykynurenine; DOPA; Pyruvic acid; Creatine; Histamine; Citrulline; alpha-D-Glucose; Cyclic AMP; 1-Methylhistidine; 5-Methoxytryptamine; Tryptophanol; Isobutyrylglycine; Acetoacetic acid; Phenylethylamine; 3-Hydroxyhippuric acid; N-a-Acetylcitrulline; Indoleacetaldehyde; |
