Study M724
Study name | Arteaga-Henriquez G 2021 |
Title | Activation and deactivation steps in the tryptophan breakdown pathway in major depressive disorder: a link to the monocyte inflammatory state of patients |
Overall design | The aim of this study was to investigate how the inflammatory monocyte state of patients with major depressive disorder (MDD) correlates to the breakdown of tryptophan to kynurenine, and of kynurenine to its potentially neurotoxic and neuroprotective downstream products. Serum levels of tryptophan, 5-hydroxytryptophan, 5-hydroxyindoleacetic acid, kynurenine, kynurenic acid, 3-hydroxykynurenine, xanthurenic acid, picolinic acid, and quinolinic acid were detected by LC-MS/MS and/or HPLC in two different cohorts of patients with MDD (MDD group, n = 281) and healthy controls (control group, n = 206). |
Study Type | Type1; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Depression; Depression; |
Criteria for depression | DSM-IV diagnosed MDD |
Sample size | 487 |
Tissue | Peripheral; Blood; Serum; |
Platform | MS-based; LC-MS: Waters Acquity UPLC separation module connected to a Xevo TQ MS triple-quadrupole mass spectrometer with a Z-spray ESI ion source (Waters Corporation, Milford, MA, USA); |
PMID | |
DOI | |
Citation | Arteaga-Henriquez G, Burger B, Weidinger E, et al. Activation and deactivation steps in the tryptophan breakdown pathway in major depressive disorder: a link to the monocyte inflammatory state of patients. Prog Neuropsychopharmacol Biol Psychiatry. 2021 Apr 20;107:110226. |
Metabolite | L-Tryptophan; 5-Hydroxyindoleacetic acid; L-Kynurenine; Kynurenic acid; Xanthurenic acid; Hydroxykynurenine; Kynurenic acid/Kynurenine ratio; |
