Study M1059
Study name | Li CC 2023 |
Title | Tryptophan-kynurenine metabolic characterization in the gut and brain of depressive-like rats induced by chronic restraint stress |
Overall design | The aim of this study was to investigate tryptophan-kynurenine metabolic characterization in the gut and brain of the chronic restraint stress (CRS) model of depression. Wistar rats were divided into the following 2 groups: (1) control group, and (2) CRS group. Rats in the CRS group were restrained in acrylic tubes for 6 h daily for four weeks. Then, cortex, hippocampus, striatum, hypothalamus, serum, colon, and cecum were collected for metabonomic analysis (n = 6/group) after behavioral tests. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Rat; Wistar rat; |
Categories of depression | Animal model; Chronic restraint stress model; Chronic restraint stress model; |
Criteria for depression | Sucrose preference test, forced swimming test |
Sample size | 12 |
Tissue | Central; Brain; Striatum; Central; Brain; Cortex; Central; Brain; Hippocampus; Peripheral; Gut; Cecum; Central; Brain; Hypothalamus; Peripheral; Blood; Serum; Peripheral; Gut; Colon; |
Platform | MS-based; LC-MS: UFLC-Q-TRAP 5500 (AB SCIEX, USA); |
PMID | |
DOI | |
Citation | Li CC, Ye F, Xu CX, et al. Tryptophan-kynurenine metabolic characterization in the gut and brain of depressive-like rats induced by chronic restraint stress. J Affect Disord. 2023 May 1;328:273-286. |
Metabolite |
