Study M982
Study name | Wang LW 2022a |
Title | Disturbance of neurotransmitter metabolism in drug-naive, first-episode major depressive disorder: a comparative study on adult and adolescent cohorts |
Overall design | The aim of this study was to investigate the tryptophan and related neurotransmitters as well as their metabolites in the circulating blood of first-episode antidepressant-naive major depressive disorder (MDD) patients. In this study, 31 first-episode adult MDD (adult MDD group), 35 healthy adults (adult control group) were recruited. To assess the effects of antidepressant treatment, the concentrations of neurotransmitters were also analyzed pre- and post-treatment. Plasma concentrations of monoamine and amino acid neurotransmitters as well as their metabolites, including tryptophan, kynurenine, kynurenic acid, serotonin, 5-hydroxyindoleacetic acid, dopamine, 3,4-dihydroxyphenylacetic acid, homovanillic acid, norepinephrine, vanillylmandelic acid, 3-methoxy-4-hydroxyphenylglycol, glutamine, glutamate and gamma-aminobutyric acid, were measured. |
Study Type | Type1; Type2; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Depression; Depression; |
Criteria for depression | DSM-IV diagnosed MDD |
Sample size | 66 |
Tissue | Peripheral; Blood; Plasma; |
Platform | MS-based; LC-MS: not reported; |
PMID | |
DOI | |
Citation | Wang L, Yang P, Yang C, et al. Disturbance of neurotransmitter metabolism in drug-naive, first-episode major depressive disorder: a comparative study on adult and adolescent cohorts. Eur Arch Psychiatry Clin Neurosci. 2022 Oct;272(7):1283-1296. |
Metabolite | L-Tryptophan; L-Glutamic acid; Homovanillic acid; 5-Hydroxyindoleacetic acid; L-Kynurenine; Kynurenic acid; 3,4-Dihydroxybenzeneacetic acid; Vanillylmandelic acid; Norepinephrine; 5-HIAA/5-HT ratio; Kynurenic acid/Kynurenine ratio; Homovanillic acid/Dopamine ratio; GABA/Glutamate ratio; |
