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Study M1105

Study name

Zhang Y 2023

Title

Implications of gut microbiota dysbiosis and fecal metabolite changes in psychologically stressed mice

Overall design

The aim of this study was to investigate effects of psychological stress on the gut microbiome and fecal metabolites. C57BL/6 J mice were divided into the following 2 groups: (1) control group, and (2) psychological stress group. Psychologically stressed mice received visual, auditory, and olfactory emotional stimuli from mice receiving electric foot shock for 14 days. Fecal metabolomics analysis was used to reveal metabolites alterations between stressed and non-stressed mice (n =  5/group).

Study Type

Type1;

Data available

Unavailable

Organism

Mouse; C57BL/6 J mouse;

Categories of depression

Animal model; Other animal model; Other animal model;

Criteria for depression

Sucrose preference test, forced swimming test

Sample size

10

Tissue

Peripheral; Faece; Faece;

Platform

MS-based; LC-MS: Vanquish UHPLC system (Thermo Fisher, Germany) with Orbitrap Q Exactive HF-X mass spectrometer (Thermo Fisher, Germany);

PMID

37213506

DOI

10.3389/fmicb.2023.1124454

Citation

Zhang Y, Zhang J, Wu J, et al. Implications of gut microbiota dysbiosis and fecal metabolite changes in psychologically stressed mice. Front Microbiol. 2023 May 5;14:1124454.

Metabolite

Citric acid;

Oleic acid;

Glutaric acid;

Homovanillic acid;

Tyramine;

Suberic acid;

5-Hydroxyindoleacetic acid;

D-Fructose;

Kynurenic acid;

Indoleacetic acid;

Hydroxyphenyllactic acid;

Hydroxykynurenine;

DOPA;

Indolelactic acid;

4-Hydroxyproline;

2-Hydroxybutyric acid;

D-Xylitol;

Gluconic acid;

Norepinephrine;

7-Methylxanthine;

Methylmalonic acid;

2-Isopropylmalic acid;

Sucrose;

LysoPC(18:1);

LysoPC(18:2);

Pipecolic acid;

N-Oleoyldopamine;

LysoPC(20:5);

Cinnamoylglycine;

Sphingosine;

1,5-Anhydrosorbitol;

Gluconolactone;

Citronellyl anthranilate;

Progesterone;

Capric acid;

4-Hydroxybenzoic acid;

Pelargonic acid;

Terephthalic acid;

Tetradecanedioic acid;

N-Acetyl-b-D-galactosamine;

2-Hydroxyvaleric acid;

6-Keto-prostaglandin F1a;

Undecylenic acid;

N-Acetylcadaverine;

D-Glucuronic acid;

2-Hydroxycaproic acid;

Oxytetracycline;

Daidzein;

L-Tyrosinemethylester;

Prostaglandin A2;

Mesalazine;

N6,N6,N6-Trimethyl-L-lysine;

Vitamin D3;

4-Methoxycinnamic acid;

5-Hydroxyindole-2-carboxylic acid;

Carnitine C18:1;

2-Naphthol;

Porphobilinogen;

Traumatic acid;

Stachyose;

N-Acetyl-D-tryptophan;

7-Methylguanine;

16,16-Dimethylprostaglandin A1;

Dodecanedioic acid;

2-Hydroxy-2-methylbutyric acid;

Stercobilin;

Soyasaponin I;

2-Linoleoyl Glycerol;

Methyl EudesMate;

Orotidine;

dIMP;

N4-Acetylcytidine;

3-amino-2-phenyl-2H-pyrazolo[4,3-c]pyridine-4,6-diol;

6-Methyladenine;

3-(3,4,5-Trimethoxyphenyl)propanoic acid;

INK;

Deacetyldiltiazem;

1-(4-hydroxyphenyl)propane-1,2-diol;

Columbianetin acetate;

Eicosa-11,14,17-trienoic acid;

19(R)-hydroxy Prostaglandin A2;

Carnitine C18:2;

17alpha,20alpha-Dihydroxypregn-4-en-3-one;

Marmesin;

Ergosta-5,7,9(11),22-Tetraen-3-beta-Ol;

4-Thiouridine;

2-Arachidonyl Glycerol ether;

3,4-Dimethoxyphenylethylamine;

N-Acetyl-DL-phenylalanine;

APH;

Undecanedioic acid;

LysoPC(16:2);

Methyl 1-(1-benzylpiperidin-4-yl)-1H-1,2,3-benzotriazole-5-carboxylate;

3-(3-bromo-4-hydroxy-5-methoxyphenyl)-2-cyanoacrylamide;

Glycyltyrosine;

Tyrosyl-Alanine;

1-(2-furyl)pentane-1,4-dione;

3-Methyladipic acid;

L-(-)-alpha-Amino-epsilon-Caprolactam;

(5S)-5-hydroxy-1,7-diphenylheptan-3-one;

Cyclamic acid;

AcylGIcADG(12:0-18:2-12:0);

R-1 Methanandamide phosphate;

2-Hydroxy-2-methyl-3-buten-1-yl beta-D-glucopyranoside;

3-(dimethylamino)-1-[4-(phenylsulfonyl)phenyl]prop-2-en-1-one;

Gibberellin A3;

RMH;

GPH;

3-Amino-4-methylpentanoic acid;

3,14-dihydro-15-keto-tetranor Prostaglandin E2;

N,N-dimethyl-5-nitro-6-[3-(trifluoromethyl)phenoxy]pyrimidin-4-amine;

N6-Succinyl Adenosine;

2,6-Dihydroxybenzoic acid;

Deisopropylatrazine;

LPG(15:0);

QKK;

4-Ethylphenol;

8-Hydroxyquinoline;

4-phenylbenzo[4,5]imidazo[1,2-a]pyrimidin-2-amine;

Saccharin;

2-hydroxyiminoindane-1,3-dione;

O,O-Diethy thiophosphate;

4-Morpholinobenzoic acid;

2-[5-(2-hydroxypropyl)oxolan-2-yl]propanoic acid;

Prostaglandin E1 Ethanolamide;

Methyl beta-D-galactopyranoside;

4-chloro-1H-indazol-3-amine;

L-(+)-Arabinose;

(R)-Lipoic acid;

6'-Sialyllactose;

D-Erythrose;

Corchorifatty acid F;

13(S)-HOTrE;

FAHFA(18:2/20:4);

15(S)-HPETE;

N1-[4-(trifluoromethyl)phenyl]-2-phenylbutanamide;

(12Z)-9,10,11-trihydroxyoctadec-12-enoic acid;

Methyl dihydrojasmonate;

Prostaglandin K2;

9-HpOTrE;

DL-2-(acetylamino)-3-phenylpropanoic acid;

(+/-)9-HpODE;

1,3-Dihydro-1,3,3-trimethy1-2H-indol-2-ylidene acetaldehyde;

5-(3-Nitrophenyl)-N-phenyloxazol-2-amine;

5-S-Cysteinyl-D-dopa;