Study M1030
Study name | Brum M 2023 |
Title | Phase-and disorder-specific differences in peripheral metabolites of the kynurenine pathway in major depression, bipolar affective disorder and schizophrenia |
Overall design | The aim of this study was to investigate if individual catabolites could serve as diagnostic biomarkers for major depressive disorder (MDD), bipolar disorder and schizophrenia. The sample consisted of 40 participants suffering from MDD in an acute episode (MDD group) and 40 healthy controls (control group). The patients received inpatient treatment, with a mean duration of 30 days. MDD participants were further classified as remitters if their MADRS scores were no more than 10 after treatment. Plasma levels of tryptophan, kynurenine, kynurenic acid, quinolinic acid and ratio of quinolinic acid/kynurenic acid were measured using liquid chromatography mass spectrometry in participants compared with controls. Differences between baseline and after treatment as usual, and between responders and non-responders were also analyzed. |
Study Type | Type1; Type2; Type4; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Depression; Depression; |
Criteria for depression | ICD-10 diagnosed MDD |
Sample size | 80 |
Tissue | Peripheral; Blood; Plasma; |
Platform | MS-based; LC-MS: LC-MS/MS (Agilent 1290 Series; API 6500 AB Sciex); |
PMID | |
DOI | |
Citation | Brum M, Nieberler M, Kehrwald C, et al. Phase-and disorder-specific differences in peripheral metabolites of the kynurenine pathway in major depression, bipolar affective disorder and schizophrenia. World J Biol Psychiatry. 2023 Jan 30:1-14. |
Metabolite |
