Study M489
Study name | Wu YJ 2018 |
Title | Kynurenine pathway changes in late-life depression |
Overall design | The aim of this study was to investigate whether tryptophan (TRP) metabolism and kynurenine (KYN) metabolism are imbalanced in late-life depression (LLD) patients and to explore the differences in kynurenine pathway (KP) characteristics between early onset depression (EOD) and late onset depression (LOD) patients. The authors investigated 170 LLD patients (depression group, EOD 90, LOD 80) and 135 normal controls (control group). Serum concentrations of TRP, KYN and kynurenic acid (KYNA) were detected by the liquid chromatography-tandem mass spectrometry method. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Geriatric depression; Geriatric depression; |
Criteria for depression | DSM-IV diagnosed MDD |
Sample size | 305 |
Tissue | Peripheral; Blood; Serum; |
Platform | MS-based; LC-MS: not reported; |
PMID | |
DOI | |
Citation | Wu Y, Zhong X, Mai N, et al. Kynurenine pathway changes in late-life depression. J Affect Disord. 2018;235:76-81. |
Metabolite | L-Tryptophan; |
