Study M806
Study name | Liu T 2021 |
Title | Investigating the basis for the antidepressant effects of Gleditsiae spina using an integrated metabolomic strategy |
Overall design | The aim of this study was to investigate the role of taxifolin as a component of Gleditsiae spina in mediating the antidepressant effects of Gleditsiae spina. Depression models in vivo were established using corticosterone. C57BL/6 mice were divided into the following 4 groups (n = 8 in each group): (1) control group, (2) corticosterone group, (3) corticosterone + fluoxetine group (corticosterone plus fluoxetine treatment at the dose of 5 mg/kg), (4) corticosterone + Gleditsiae spina group (corticosterone plus Gleditsiae spina treatment at the dose of 3.33 g/kg), and (5) corticosterone + taxifolin group (corticosterone plus taxifolin treatment at the dose of 0.1 g/kg). The corticosterone injection lasted for 3 weeks, and drugs were administered orally during the model building period. A simultaneous metabolomic approach was used to compare the systemic effects of Gleditsiae spina and taxifolin in urine samples through metabolic networks. |
Study Type | Type1; Type2; |
Data available | Unavailable |
Organism | Mouse; C57BL/6 mouse; |
Categories of depression | Animal model; Other animal model; Other animal model; |
Criteria for depression | Sucrose preference test |
Sample size | 40 |
Tissue | Peripheral; Urine; Urine; |
Platform | MS-based; LC-MS: Ultra Performance Liquid Chromatography system (Dionex; UltiMate 3000 System, Thermo Scientific, USA) coupled to Q/TOF mass spectrometer system; |
PMID | |
DOI | |
Citation | Liu T, Zhou N, Cao Y, et al. Investigating the basis for the antidepressant effects of Gleditsiae spina using an integrated metabolomic strategy. Iran J Basic Med Sci. 2021 Apr;24(4):524-530. |
Metabolite | Citric acid; L-Phenylalanine; L-Proline; L-Methionine; L-Asparagine; Hippuric acid; Succinic acid; L-Tyrosine; L-Arginine; Pantothenic acid; Kynurenic acid; Phenylacetylglycine; Xanthurenic acid; Oxoglutaric acid; Uric acid; Taurine; Betaine; Creatine; N-Acetyl-L-glutamic acid; cis-Aconitic acid; 1-Methylnicotinamide; L-Carnitine; Nicotinic acid; Allantoin; Spermidine; Cytidine monophosphate; 3-(3-Hydroxyphenyl)propanoic acid; Trigonelline; Cortisol; Carnosine; Gulonic acid; 5-Methoxyindoleacetate; 2-Hydroxyethanesulfonate; Dimethyl sulfone; 2-Phenylacetamide; Nicotinuric acid; Gentisic acid; Urocanic acid; Protocatechuic acid; N-Acetyl-L-phenylalanine; Sulfate; N-Formyl-L-methionine; L-2-Amino-3-oxobutanoic acid; 5-L-Glutamyl-taurine; 3-Hydroxy-L-proline; N-Acetylputrescine; L-Lyxonic acid; (2R)-2-Hydroxy-2-methylbutanenitrile; Valproic acid; L-Rhamnulose; 2,5-Dioxopentanoate; D-Xylono-1,5-lactone; D-Ribulose; |
