Study M928

Study name

Xie J 2022

Title

Associations between disordered microbial metabolites and changes of neurotransmitters in depressed mice

Overall design

The aim of this study was to explore the relationships between microbial metabolites in feces and neurotransmitters in prefrontal cortex of chronic unpredictable mild stress (CUMS) model of depressed mice. C57BL/6 mice were divided into the following 2 groups (n = 10 in each group): (1) control group, and (2) CUMS group. CUMS stress procedure lasted for 4 weeks. Targeted liquid chromatography-mass spectrometry analysis was used to detect the microbial metabolites in feces and neurotransmitters in prefrontal cortex of mice.

Study Type

Type1;

Data available

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9163491/bin/Table_1.xlsx

Organism

Mouse; C57BL/6 mouse;

Categories of depression

Animal model; Chronic mild stress model; Chronic mild stress model;

Criteria for depression

Sucrose preference test, forced swimming test

Sample size

20

Tissue

Central; Brain; Prefrontal cortex;

Peripheral; Faece; Faece;

Platform

MS-based; LC-MS: Agilent 1290 infinity LC ultra high performance liquid chromatography system with 5500 qtrap mass spectrometer (AB SCIEX);

MS-based; LC-MS: Agilent 1290 infinity LC ultra high performance liquid chromatography system with AB 6500 qtrap mass spectrometer was used (AB SCIEX);

PMID

35669116

DOI

10.3389/fcimb.2022.906303

Citation

Xie J, Wang Y, Zhong Q, et al. Associations between disordered microbial metabolites and changes of neurotransmitters in depressed mice. Front Cell Infect Microbiol. 2022 May 20;12:906303.

Metabolite

Gamma-Aminobutyric acid;

Pyroglutamic acid;

Palmitoleic acid;

L-Phenylalanine;

L-Tryptophan;

L-Valine;

L-Proline;

L-Glutamic acid;

Glycine;

L-Serine;

L-Threonine;

Arachidonic acid;

L-Methionine;

L-Lactic acid;

L-Alanine;

L-Asparagine;

L-Glutamine;

L-Aspartic acid;

Indole-3-propionic acid;

L-Lysine;

Homovanillic acid;

Succinic acid;

L-Tyrosine;

2-Furoic acid;

D-Glucose;

L-Arginine;

Choline;

Threonic acid;

Cholic acid;

Chenodeoxycholic acid;

Oxoglutaric acid;

Indoxyl sulfate;

Serotonin;

Glucose 6-phosphate;

Taurine;

L-Histidine;

Histamine;

Docosahexaenoic acid;

Beta-Alanine;

cis-Aconitic acid;

Norepinephrine;

Ornithine;

NAD;

Biotin;

L-Malic acid;

Guanosine monophosphate;

Methylmalonic acid;

Adenosine monophosphate;

Alpha-ketoisovaleric acid;

Aminoadipic acid;

N-Acetyl-L-alanine;

L-Carnitine;

Sarcosine;

N-Acetyl-D-glucosamine;

Nicotinic acid;

Erythronic acid;

ADP;

Allantoin;

Acetamide;

Deoxycholic acid;

Normetanephrine;

Folic acid;

Carnosine;

L-Homoserine;

Hyodeoxycholic acid;

Murocholic acid;

Methylcysteine;

Hydroxypropionic acid;

Gluconolactone;

Muricholic acid;

Epinephrine;

Anandamide;

Acetylcholine;

Leucyl-Glycine;

Chenodeoxycholic acid glycine conjugate;

Dihomo-gamma-linolenic acid;

Anserine;

L-Thyronine;

Docosadienoate (22:2n6);

D-2-Hydroxyglutaric acid;

Adrenic acid;

N-Acetylserine;

gamma-Glutamylalanine;

Phenylacetylglutamine;

Erucic acid;

Norvaline;

Indoxyl glucuronide;

Docosapentaenoic acid (22n-6);

Sulfolithocholylglycine;

NADPH;

Ursodeoxycholic acid;

2-Phenylglycine;

5-Hydroxylysine;

Palmitelaidic acid;

Malonyl-CoA;

L-3-Hydroxykynurenine;

3-dehydrocholate;

7-dehydrocholate;

Apocholic acid;

3a,6b,7b-Trihydroxy-5b-cholanoic acid;

Beta-Ursodeoxycholic acid;

Isodeoxycholic acid;

Ursocholic acid;

NADH;

Dihomo-alpha-linolenic acid;