Study M712

Study name	Zheng P 2020
Title	The gut microbiome modulates gut-brain axis glycerophospholipid metabolism in a region-specific manner in a nonhuman primate model of depression
Overall design	In this study, microbial composition and function and gut-brain metabolic signatures in female cynomolgus macaque (Macaca fascicularis) displaying naturally occurring depressive-like behaviors were characterized. Cynomolgus monkeys were divided into the following 2 groups (n = 6 per group): (1) control group (cynomolgus macaques without depressive-like behavior), and (2) depression group (cynomolgus macaques with depressive-like behavior). Metabolite profiles of peripheral and brain tissue samples (feces, intestine, liver, serum, prefrontal cortex, hippocampus, and amygdala) were compared using both GC-MS and LC-MS.
Study Type	Type1;
Data available	Unavailable
Organism	Non-human primate; Cynomolgus monkey;
Categories of depression	Animal model; Other animal model; Other animal model;
Criteria for depression	Behavioral observation
Sample size	12
Tissue	Peripheral; Gut; Intestine; Peripheral; Faece; Faece; Central; Brain; Prefrontal cortex; Central; Brain; Hippocampus; Peripheral; Liver; Liver; Peripheral; Blood; Serum; Central; Brain; Amygdala;
Platform	MS-based; GC-MS: not reported; MS-based; LC-MS: not reported;
PMID	32376998
DOI	10.1038/s41380-020-0744-2
Citation	Zheng P, Wu J, Zhang H, et al. The gut microbiome modulates gut-brain axis glycerophospholipid metabolism in a region-specific manner in a nonhuman primate model of depression. Mol Psychiatry. 2020.
Metabolite	Linoleic acid; Pyroglutamic acid; Oleic acid; 3-Hydroxybutyric acid; Myristic acid; Palmitoleic acid; L-Phenylalanine; L-Proline; L-Glutamic acid; L-Serine; Arachidonic acid; Homovanillic acid; Succinic acid; Caproic acid; D-Glucose; Uridine; L-Cystine; Dimethylglycine; Pseudouridine; Creatinine; Vanylglycol; Uracil; Betaine; Indolelactic acid; Beta-Alanine; Inosine; Norepinephrine; Citrulline; 1-Methylhistidine; 2-Aminomuconic acid semialdehyde; N-Acetylserotonin; LysoPC(18:0); Adenosine triphosphate; 3-Phosphoglyceric acid; Fructose 1,6-bisphosphate; L-Malic acid; Adenosine; Guanosine monophosphate; Adenosine monophosphate; Oxidized glutathione; Alpha-ketoisovaleric acid; Glycerophosphocholine; 2-Hydroxyglutarate; Ureidosuccinic acid; Sarcosine; Nicotinic acid; D-Galactose; Heptadecanoic acid; 5-Aminopentanoic acid; LysoPC(15:0/0:0); Phosphoenolpyruvic acid; Cytosine; Uridine 5'-monophosphate; Glutathione; D-Sedoheptulose 7-phosphate; Glyoxylic acid; LysoPC(16:1/0:0); PC(32:0); 11Z-Eicosenoic acid; D-Arabitol; Carnosine; Acetylcysteine; Mannose 6-phosphate; Dimethyl sulfone; LysoPC(14:0); Cer(d18:1/18:0); Cer(d18:1/20:0); LysoPC(20:0/0:0); Pregnenolone; Allopregnanolone; Pregnenolone sulfate; Prostaglandin E2; Asymmetric dimethylarginine; Oleoylethanolamide; LysoPC(20:4/0:0); 13-HODE; 4-Acetamidobutanoic acid; Galactinol; LysoPE(20:4(5Z,8Z,11Z,14Z)/0:0); PI(18:0/0:0); LysoPE(22:4(7Z,10Z,13Z,16Z)/0:0); PE(18:2(9Z,12Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z)); PE(20:4(5Z,8Z,11Z,14Z)/P-16:0); PC(16:0/P-18:1(11Z)); Dodecanoic acid; 3-Carboxy-4-methyl-5-propyl-2-furanpropionic acid; Cer(d18:0/24:0); Hydrocinnamic acid; LysoPC(17:0/0:0); Nicotianamine; 2E,4E,8Z,10E-Dodecatetraenoic acid; LysoPC(18:1(9Z)); Cholesterol sulfate; 6-deoxyerythronolide B; 1-Heptene; Pyridoxal; MG(18:0/0:0/0:0); Aminoacetone; LysoPC(22:4(7Z,10Z,13Z,16Z)/0:0); LysoPC(22:5(4Z,7Z,10Z,13Z,16Z)/0:0); PC(15:0/22:6(4Z,7Z,10Z,13Z,16Z,19Z)); PE(22:5(4Z,7Z,10Z,13Z,16Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z)); CE(20:0); 3-Sulfinoalanine; 1-Methylhistamine; all-trans-Retinoic acid; Hypericin; m-Cresol; 9,12,13-TriHOME; (23S)-1alpha-hydroxy-25,27-didehydrovitamin D3 26,23-lactone; 11,15-Dimethyltritriacontane; 11-Methylhexacosane; 12,13-Dimethyl-5,14-dioxabicyclo[9.2.1]-tetradeca-1(13),11-dien-4-one; 13,14-dihydroxy-docosanoic acid; 14-methyl-8-hexadecen-1-ol; 14-O-(beta-D-glucopyranosyl)-7S,14R-dihydroxy-7,9,13,17-tetramethyl-2E,4E,8E,10E,12E,16E-octadecahexaenoic acid; 15-HETE-DA; 19,20-DiHDPA; 24:3(15Z,18Z,21Z); 24-Nor-5beta-chol-22-ene-3alpha,7alpha,12alpha-triol; Shibic acid; 2-deoxy-20-hydroxy-5alpha-ecdysone 3-acetate; 2-methyl-2-dodecenoic acid; 3-Oxooctanoic acid; 3'-O-methylbatatasin III; (S)-2,3-Epoxysqualene; 3Z,6Z,9Z,12Z,15Z-Tricosapentaene; 3Z,6Z-Eicosadiene; 5,7,4'-Trihydroxyflavanone 7-sulfate; 5alpha,9alpha-epidioxy-cholest-7-en-3beta,6alpha-diol; 5alpha-Cholestane-3alpha,7alpha,16alpha,26-tetrol; 5-Carboxypyranocyanidin 3-O-beta-glucopyranoside; 5-HEPE; 7-Acetoxy-7,8-dihydroiodovulone I; 7-Ethyl-3,11-dimethyl-1,3Z,6E,10-tridecatetraene; 7-Ketocholesterol; 8-Amino-7-oxononanoic acid; Artelastochromene; 1,4-Dimethyl-7-ethylazulene; Coumesterol; CPA(18:1(9Z)/0:0); Dehydrodolineone; Diaminopimelic acid; Homocysteine thiolactone; Hydroxyphthioceranic acid (C31); Hydroxyphthioceranic acid (C42); Ibuprofen; Isorhamnetin 3-(6''-galloylglucoside); Leukotriene B4; LysoPC(22:1(13Z)/0:0); Makisterone B; Malvidin 3-glucoside-5-(6''-malonylglucoside); Minabeolide-1; N,N-(2,2-dihydroxy-ethyl) arachidonoyl amine; Naringenin 7-O-(2'',6''-di-O-alpha-rhamnopyranosyl)-beta-glucopyranoside; N-linolenoyl-glutamine; PA(18:1(9Z)/0:0); PA(19:1(9Z)/0:0); PA(O-16:0/14:0); PA(P-16:0/15:1(9Z)); PC(13:0/0:0); PC(15:1(9Z)/0:0); PC(16:0/2:0); PC(17:1(10Z)/0:0); PC(18:0/2:0); PC(18:1(9Z)/4:0); PC(19:1(9Z)/0:0); PC(19:3(10Z,13Z,16Z)/0:0); PC(O-11:1(10E)/2:0); PC(O-12:0/O-2:0); PC(O-15:0/0:0); PC(O-16:0/0:0); PC(O-16:0/O-2:0); PC(O-17:0/0:0); PC(O-18:0/14:0); PC(O-18:0/O-2:1(1E)); PC(O-6:0/O-6:0); PE(14:0/15:0); PE(14:0/18:2(9Z,12Z)); LysoPE(20:1(11Z)/0:0); PE(O-18:0/O-18:0); PE(O-20:0/0:0); 3,5,7-trihydroxy-2-(4-hydroxy-3-methoxyphenyl)-1λ⁴-chromen-1-ylium; PG(20:4(5Z,8Z,11Z,14Z)/0:0); PG(22:4(7Z,10Z,13Z,16Z)/0:0); PGH2-EA; PI(O-18:0/0:0); Pongamoside A; Primflaside; PS(18:4(6Z,9Z,12Z,15Z)/22:4(7Z,10Z,13Z,16Z)); PS(22:1(11Z)/0:0); PS(O-18:0/0:0); Thonningianin B; Topiramate; Tricosanyl palmitoleate; Viscutin 1; zymosterol intermediate 1c; Mannonic acid; Hydroxycarbamate; 1,2,4-Benzenetriol; 11alpha-(chloromethyl)-1alpha,25-dihydroxyvitamin D3 / 11alpha-(chloromethyl)-1alpha,25-dihydroxycholecalciferol; 12-bromo-octadecanoic acid; 1alpha-hydroxy-26,27-dinorvitamin D3 25-carboxylic acid / 1alpha-hydroxy-26,27-dinorcholecalciferol 25-carboxylic acid; 1beta-Hydroxycholic acid; 2-hydroxy-tridecanoic acid; 7alpha,12alpha,25-Trihydroxycholest-4-en-3-one; 7-oxo-8-amino-nonanoic acid; Caloxanthin sulfate; (+)-Dysideapalaunic acid; (6RS)-22-oxo-23,24,25,26,27-pentanorvitamin D3 6,19-sulfur dioxide adduct / (6RS)-22-oxo-23,24,25,26,27-pentanorcholecalciferol 6,19-sulfur dioxide adduct; (S)-dihydrolipoic acid; 1-(6-[5]-ladderane-hexanyl)-2-(8-[3]-ladderane-octanyl)-sn-glycerol; 1-(8-[5]-ladderane-octanoyl)-2-(8-[3]-ladderane-octanyl)-sn-glycerophosphoethanolamine; 1'',2''-Dihydro-8-hydroxyisopentanyl-3'-methoxy-4'-O-methylalpinumisoflavone; 1,7Z,13Z-Pentacosatriene; (9E)-10-nitrooctadecenoic Acid; 10Z,13Z,16Z-nonadecatrienenitrile; 11-dehydro-2,3-dinor-TXB2; 15-HETE-T; 16a-Hydroxyestrone; 17-Phenyl-trinor-PGF2alpha amide; 1alpha,25-Dihydroxy-21-nor-20-oxavitamin D3 / 1alpha,25-dihydroxy-21-nor-20-oxacholecalciferol; 1alpha-Hydroxy-26,27-dinorvitamin D3 25-carboxylic acid / 1alpha-hydroxy-26,27-dinorcholecalciferol 25-carboxylic acid; 1-Tetradecanyl-2-(8-[3]-ladderane-octanyl)-sn-glycerol; 2,4-Dihydroxychalcone; 20-Carboxy-leukotriene B4; 26:2(5Z,9Z)(25Me); 3beta,4beta,5-Trimethoxy-4'-hydroxy- (6:7)-2,2-dimethylpyranoflavan; 3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carbaldehyde; 3Z,6Z,9Z,12Z,15Z-Pentacosapentaene; 3Z,6Z,9Z-Octadecatriene; 4-Hydroxy-2-oxoheptanedioic acid; 4-oxo-Retinoic acid; 5,7-Dimethoxy-8-prenylflavan; Tetracosapentaenoic acid (24:5n-6); 7-Geranylformononetin; 7-Methyl-6E-hexadecenoic acid; 9,10-Tetracosadiene; 9,11alpha-epoxypregn-4-ene-3,20-dione; 9(S)-HPOT; Bisdemalonylmonardaein; DG(18:1(11Z)/22:5(4Z,7Z,10Z,13Z,16Z)/0:0); DMG-MINO; Docosatrienoic acid; Dopamine 4-sulfate; Fucoxanthin; N-gamma-Glutamylglutamine; Gibberellin A36; GlcCer(d18:1/18:1(9Z)); (-)-Gossypol; MGDG(18:3(9Z,12Z,15Z)/16:3(7Z,10Z,13Z)); Mycolipenic acid (C28); N-arachidonoyl GABA; N-palmitoyl methionine; PA(14:0/18:1(9Z)); PA(O-16:0/18:2(9Z,12Z)); PA(P-18:0/20:5(5Z,8Z,11Z,14Z,17Z)); PC(20:4(5Z,8Z,11Z,14Z)/24:1(15Z)); PE(14:0/22:2(13Z,16Z)); PE(15:1(9Z)/0:0); PE(18:3(9Z,12Z,15Z)/20:2(11Z,14Z)); LysoPE(20:3(8Z,11Z,14Z)/0:0); PE(22:2(13Z,16Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z)); PE(P-18:1(11Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z)); PG(18:1(9Z)/12:0); PI(20:0/22:2(13Z,16Z)); PS(17:0/20:3(8Z,11Z,14Z)); Quassin; Serpyllin; Tephrowatsin B; Tetrahydrocortisone; Villosin; Octadecanol; Glycerol-1-phosphate; 3-Arylcarbonyl-alanine; Galactose-6-phosphate; (-)-11-hydroxy-9,10-dihydrojasmonic acid 11-beta-D-glucoside; (6R)-25-hydroxyvitamin D3 6,19-sulfur dioxide adduct / (6R)-25-hydroxycholecalciferol 6,19-sulfur dioxide adduct; Dehydrovomifoliol; 12,13-DiHODE; 13-chloro-docosane-1,14-disulfate; 15-deoxy-delta-12,14-PGJ2-d4; 1alpha,25-Dihydroxyvitamin D3 25-trimethylsilyl ether; 26,27-diethyl-1alpha,25-dihydroxy-22-thiavitamin D3 / 26,27-diethyl-1alpha,25-dihydroxy-22-thiacholecalciferol; 2(R)-hydroxyicosanoic acid; 3alpha,7beta,12alpha-Trihydroxy-6-oxo-5alpha-cholan-24-oic Acid; 3'-Deoxydryopteric acid; 3E,5E-tridecadienoic acid; 3-O-alpha-L-Rhamnopyranosyl-3-hydroxydecanoyl-3-hydroxydecanoic acid; 4-[5]-Ladderane-butanoic acid; 4'-Hydroxy-4-(4-hydroxystyryl)-5,7-dimethoxyflavan; 9,10-DHOME; 9S,10S,11R-trihydroxy-12Z,15Z-octadecadienoic acid; Acetaldehyde; Alhpa-tocopheronic acid; DG(18:2(9Z,12Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z)/0:0); Digoxin; Estriol 3-sulfate 16-glucuronide; Fumagillin; Glepidotin C; Methyl 8-[2-(2-formyl-vinyl)-3-hydroxy-5-oxo-cyclopentyl]-octanoate; Mevalonic acid; MGDG(16:0/18:2(9Z,12Z)); N-(6-Aminohexanoyl)-6-aminohexanoic acid; N-Methyl arachidonoyl amine; PC(14:1(9Z)/24:1(15Z)); PC(7:0/0:0); PE(12:0/15:1(9Z)); PE(O-16:0/21:0); PS(10:0/10:0); Sphingosine-1-phosphocholine; Xestoaminol C; 21-Hydroxy-heneicosanoic acid; 2-Amino-14,16-dimethyloctadecan-3-ol; 2(R)-hydroxydocosanoic acid; 2-Oxo-tricosanoic acid; Anastatin A; Epinephrine sulfate; Gibberellin A53; PC(16:0/5:0); PE(14:0/P-18:0); PS(O-16:0/22:6(4Z,7Z,10Z,13Z,16Z,19Z)); Terpentecin; 1-Butylamine; Conduritol-beta-epoxide; 12beta-Hydroxy-24-norcholesta-1,4,22E-trien-3-one; 1alpha,24-dihydroxy-25,26,27-trinorvitamin D3 / 1alpha,24-dihydroxy-25,26,27-trinorcholecalciferol; 27-Nor-22R-hydroxy-5alpha-cholestan-3,6-dione; 3,7,11-Trimethyldodeca-2E,4E-diene; 3Z,6Z,9Z-Pentacosatriene; 5,8,11-Dodecatriynoic acid; 9-Hexadecen-1-ol; Anandamide (20:2, n-6); Neomethymycin; N-Stearoyl GABA; 1-(7Z,10Z,13Z,16Z-docosatetraenoyl)-glycero-3-phosphate; PGE2alpha dimethyl amine; Lactobionic acid; 7,4'-Dihydroxy-8-methylflavan; Daidzein; PE(14:0/22:6(4Z,7Z,10Z,13Z,16Z,19Z)); 12beta,16beta,20R-Trihydroxy-cholest-1,4-dien-3-one; 13-Keto-9Z,11E,15Z-Octadecatrienoic acid; 13-Tetradecen-2,4-diyn-1-ol; 16,16-Dimethyl-PGE1; 1-Octacosene; 2,6,8,12-Tetramethyl-2,4-tridecadien-1-ol; Alpha-Ketooctanoic acid; 3beta-Hydroxy-5alpha,6alpha-epoxy-9-oxo-9,10-seco-5-cholest-7-en-11-al; 3-Hydroxysuberic acid; 5,7,3',5'-Tetrahydroxy-3,6,8,4'-tetramethoxyflavone; 5S,9S-Dimethyloctadecane; 8beta-Hydroxy-3-longipinen-5-one; Caffeine; Cer(d18:0/25:0); DG(22:5(4Z,7Z,10Z,13Z,16Z)/24:1(15Z)/0:0); GlcCer(d16:1/23:0); Isovaleraldehyde; Luteolin 7-glucuronosyl-(1->2)-glucuronide-4'-glucuronide; LysoPC(18:4(6Z,9Z,12Z,15Z)/0:0); p-Menthan-3-ol; PA(18:1(11Z)/18:1(11Z)); PC(O-16:0/O-18:1(9Z)); PE(14:0/18:3(9Z,12Z,15Z)); PE(14:1(9Z)/24:0); PE(18:1(11Z)/18:1(11Z)); PG(20:2(11Z,14Z)/22:4(7Z,10Z,13Z,16Z)); PGF2alpha-11-acetate; PGF2alpha-EA(d4); PI(20:4(5Z,8Z,11Z,14Z)/16:1(9Z)); Prosafrinine; PS(18:1(9Z)/20:4(5Z,8Z,11Z,14Z)); Resolvin D1; Sophoracoumestan A; Tetrahydrocurcumin; TG(12:0/12:0/18:1(9Z)); TG(16:1(9Z)/16:1(9Z)/16:1(9Z)); Maltotriose; Digalacturonic acid; 18-Nonadecynoic acid; 19-Norcholestenone; 3-Demethylubiquinone-9; 5,7,3',4'-Tetrahydroxy-6,5'-di-C-prenylflavanone; Adonixanthin 3-glucoside; Antiarone D; Fumonisin A1; Muxiangrin III; PA(17:2(9Z,12Z)/0:0); PC(20:5(5Z,8Z,11Z,14Z,17Z)/24:1(15Z)); PE(22:4(7Z,10Z,13Z,16Z)/24:1(15Z)); PEP-16:0/18:1(11Z)); Prebarbigerone; 10E-Heptadecen-8-ynoic acid; 3,5,7-Trimethyl-2E,4E,6E,8E-undecatetraene; 3-Buten-2-one; 7-Hydroxyflavan; Ambrettolic acid; CerP(d18:1/18:0); N-Ethyl arachidonoyl amine; PA(14:0/12:0); LysoPG(18:1(9Z)/0:0); PS(12:0/17:0); TG(18:2(9Z,12Z)/14:0/18:3(9Z,12Z,15Z)); Cyanoalanine; (E)-4-Nitrostilbene; 24,24-Difluoro-1alpha-hydroxyvitamin D3 / 24,24-Difluoro-1alpha-hydroxycholecalciferol; 2-Oxo-heneicosanoic acid; 6Z,9Z-Pentacosadiene; 7-Dehydrocholesterol; 9Z,11E,13-Tetradecatrienal; C17 Sphinganine-1-phosphate; DG(14:0/18:3(6Z,9Z,12Z)/0:0); (+)-Limonene; Farnesyl triphosphate; Gama-Tocopherol; Heneicosanedioic acid; Hippuristanolide; Kazinol H; Mutisianthol; Ophionin; PA(16:0/0:0); PA(17:1(9Z)/22:2(13Z,16Z)); PA(18:0/0:0); 1-(11Z-eicosenoyl)-glycero-3-phosphate; 1-(11Z-docosenoyl)-glycero-3-phosphate; PA(P-18:0/0:0); PC(10:0/10:0); PC(16:0/3:1(2E)); PC(16:0/O-1:0); PC(18:1(9E)/2:0); PC(22:4(7Z,10Z,13Z,16Z)/P-18:0); PE(18:2(9Z,12Z)/20:5(5Z,8Z,11Z,14Z,17Z)); PE(18:4(6Z,9Z,12Z,15Z)/22:5(4Z,7Z,10Z,13Z,16Z)); Pelargonidin 3-(6''-malonylglucoside)-5-glucoside; Pelargonidin 3-sambubioside-5-glucoside; PI(18:2(9Z,12Z)/0:0); Protorifamycin I; Undecaprenyl phosphate; (+)-Hirusten-12-oic acid; (+)-Myristinin A; (21-Methyl-8Z-pentatriacontene; 11alpha-(4-dimethylaminophenyl)-1alpha,25-dihydroxyvitamin D3 / 11alpha-(4-dimethylaminophenyl)-1alpha,25-dihydroxycholecalciferol; 2,5-Dimethyl-2E-tridecenoic acid; 2E,4E,6E-Nonatrienal; 2E-Hexene; 3,5-Di-O-methyl-8-prenylafzelechin-4beta-ol; Geranylcitronellol; 3alpha,12alpha-Dihydroxy-6-oxo-5beta-chol-7-en-24-oic acid; 4,2',4'-Trihydroxy-3-methoxydihydrochalcone; 4-Heptanone; 6-[3]-Ladderane-1-hexanol; beta-Vinyl acrylic acid; Cucurbitacin H; DG(14:1(9Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z)/0:0); DG(20:4(5Z,8Z,11Z,14Z)/22:5(4Z,7Z,10Z,13Z,16Z)/0:0); DHA (d5); Dimethylallylpyrophosphate; Docosanedioic acid; PC(18:0/22:5(7Z,10Z,13Z,16Z,19Z)); PC(18:2(9Z,12Z)/20:5(5Z,8Z,11Z,14Z,17Z)); PG(14:0/0:0); PG(16:0/22:4(7Z,10Z,13Z,16Z)); PG(18:2(9Z,12Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z)); PI(16:0/20:2(11Z,14Z)); PI(16:0/22:5(4Z,7Z,10Z,13Z,16Z)); PI(20:3(8Z,11Z,14Z)/0:0); PI(P-18:0/19:1(9Z)); Scillirosidin; SM(d16:1/17:0); SM(d16:1/18:1); SM(d18:1/18:1(9Z)); Stoloniferone F; Isochlorogenic acid; 2,5-Dihydroxypyrazine; Palatinitol; 10-oxo-docosanoic acid; 2-Chlorohexadecanol; 2-Fluoro-hexadecanoic acid; 3,4-Didehydro-beta-carotene; 3-O-alpha-L-Rhamnopyranosyl-3-hydroxydecanoic acid; 4,7,10,13-Docosatetraynoic acid; 9-pentadecen-1-ol; Axillarin 7-sulfate; Grandiflorone; Isorhamnetin 3-glucuronide-7-sulfate; PG(20:5(5Z,8Z,11Z,14Z,17Z)/0:0); PI(20:1(11Z)/22:2(13Z,16Z)); Plastoquinol-1; PS(12:0/0:0); PS(O-20:0/0:0); 13E,15E,18Z,20Z-pentacosatetraen-11-ynyl acetate; 4,8-Dimethyl-4E,8E-decadien-10-olide; Bismuth; Briantheine W; Butyl 4'-O-butanoyl-6-O-hexadecanoyl-neohesperidoside; DG(22:2(13Z,16Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z)/0:0); LysoPC(14:1(9Z)/0:0); Millettocalyxin C; Levonorgestrel; PC(20:1(11Z)/P-18:1(11Z)); PC(O-10:1(9E)/2:0); Pilosanol A; Pristanic acid;