Study M555
Study name | Lv WJ 2019 |
Title | The gut microbiome modulates the changes in liver metabolism and in inflammatory processes in the brain of chronic unpredictable mild stress rats |
Overall design | The aim of this study was to determine how gut microbiome contributes to the process of depression and further influences the host. Chronic unpredictable mild stress (CUMS) was used to establish a depression model. Fecal microbiota transplant (FMT) is applied to illustrate that depression can be transmitted via microbiota, and metabolism of liver analysis is applied to demonstrate further influence to the liver. Antibiotic-treated Sprague-Dawley rats were divided into the following 2 groups (n = 8 in each group): (1) control group (rats received fecal stools from control rats), (2) FMT group (rats received fecal stools from CUMS rats). On the 7th day after FMT, there was a significant difference in behavior in the tail suspension test between the control group and FMT group rats. Alterations of liver metabolites in FMT rats were determined by LC-MS. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Rat; Sprague-Dawley rat; |
Categories of depression | Animal model; Other animal model; Other animal model; |
Criteria for depression | Tail suspension test |
Sample size | 16 |
Tissue | Peripheral; Liver; Liver; |
Platform | MS-based; LC-MS: UHPLC and subjected to mass spectrometry using a Triple TOF 5600 mass spectrometer (AB SCIEX); |
PMID | |
DOI | |
Citation | Lv WJ, Wu XL, Chen WQ, et al. The gut microbiome modulates the changes in liver metabolism and in inflammatory processes in the brain of chronic unpredictable mild stress rats. Oxid Med Cell Longev. 2019;2019:7902874. |
Metabolite | Glyceric acid; Linoleic acid; Glycerol; Myristic acid; Palmitoleic acid; Palmitic acid; L-Phenylalanine; L-Tryptophan; L-Valine; L-Leucine; L-Glutamic acid; Arachidonic acid; L-Isoleucine; L-Methionine; L-Glutamine; L-Aspartic acid; L-Lysine; Succinic acid; L-Tyrosine; Pantothenic acid; Threonic acid; Hypoxanthine; Uracil; Hypotaurine; L-Histidine; Gluconic acid; Docosahexaenoic acid; D-Ribose; Xanthosine; Citrulline; alpha-D-Glucose; Dihydroxyacetone phosphate; 5'-Methylthioadenosine; Adenosine; Phosphorylcholine; D-Ribose 5-phosphate; Adenine; Ribitol; Cytidine; Glutathione; 4-Pyridoxic acid; Thymine; Taurochenodesoxycholic acid; D-Tagatose; Alpha-Linolenic acid; Phenyllactic acid; Glucosamine-1P; D-Serine; 13-HODE; LysoPE(16:0/0:0); Allose; Dodecanoic acid; Eicosapentaenoic acid; Dihydrothymine; Docosapentaenoic acid (22n-3); Dihomo-gamma-linolenic acid; Norethindrone Acetate; 2E-Eicosenoic acid; Juniperic acid; Muramic acid; DL-Lactate; Pentadecanoic acid; Stearidonic acid; D-Glucaric acid; N-Acetylneuraminic acid; 10-Hydroxydecanoic acid; |
