Study M1090

Study name

Zhang BH 2023

Title

Hyperbaric oxygen improves depression-like behaviors in chronic stress model mice by remodeling gut microbiota and regulating host metabolism

Overall design

The aim of this study was to investigate whether hyperbaric oxygen treatment improves depression-like behaviors in chronic unpredictable mild stress (CUMS) model mice. BALb/c mice were divided into the following 4 groups (n = 7 in each group): (1) control group (non-stress), (2) CUMS group (stress), (3) hyperbaric oxygen treatment (non-stress with hyperbaric oxygen treatment), and (4) CUMS + hyperbaric oxygen treatment group (stress with hyperbaric oxygen treatment). The CUMS stress procedure lasted for 5 weeks, and hyperbaric oxygen treatment remained for 21 days. The plasma samples were used for metabolomics analysis.

Study Type

Type1;

Type2;

Type3;

Data available

Unavailable

Organism

Mouse; BALb/c mouse;

Categories of depression

Animal model; Chronic mild stress model; Chronic mild stress model;

Healthy individuals; Healthy individuals; Healthy individuals;

Criteria for depression

Forced swimming test, tail suspension test

Sample size

28

Tissue

Peripheral; Blood; Plasma;

Platform

MS-based; LC-MS: Ultimate 3000 UHPLC system (Thermo Scientific) with Thermo Scientific Q-Exactive MS;

PMID

36261870

DOI

10.1111/cns.13999

Citation

Zhang B, Dong W, Ma Z, et al. Hyperbaric oxygen improves depression-like behaviors in chronic stress model mice by remodeling gut microbiota and regulating host metabolism. CNS Neurosci Ther. 2023 Jan;29(1):239-255.

Metabolite

myo-Inositol;

Gamma-Aminobutyric acid;

Linoleic acid;

Pyroglutamic acid;

Oleic acid;

Stearic acid;

Myristic acid;

Palmitoleic acid;

Palmitic acid;

N-Acetyl-L-aspartic acid;

L-Glutamic acid;

L-Alanine;

Suberic acid;

Sebacic acid;

Uridine;

Choline;

L-Cystine;

Xanthurenic acid;

Indoleacetic acid;

Indoxyl sulfate;

Hypoxanthine;

3-Methoxytyrosine;

Fructose 6-phosphate;

4-Hydroxyproline;

Inosine;

Norepinephrine;

Xanthosine;

Dopamine;

Ornithine;

5'-Methylthioadenosine;

Adenosine;

Phosphorylcholine;

Oxidized glutathione;

D-Ribose 5-phosphate;

Aminoadipic acid;

2-Hydroxyglutarate;

Ureidosuccinic acid;

Sucrose;

Nicotinic acid;

Heptadecanoic acid;

Phosphoenolpyruvic acid;

L-Cystathionine;

4-Pyridoxic acid;

Thymine;

Deoxyguanosine;

Riboflavin;

Guanosine;

O-Phosphoethanolamine;

L-Allothreonine;

N-Acetylleucine;

D-Xylose;

L-Palmitoylcarnitine;

Alpha-Linolenic acid;

Guanidinosuccinic acid;

Picolinic acid;

Mannose 6-phosphate;

4-Hydroxyphenylpyruvic acid;

Thiamine;

Gluconolactone;

5-Hydroxy-L-tryptophan;

Acetylcholine;

N-Acetylaspartylglutamic acid;

Succinyladenosine;

FAD;

Urocanic acid;

Capric acid;

Eicosapentaenoic acid;

Guanine;

Alpha-Lactose;

Anserine;

Indole;

Pyridoxal;

N-acetylhistamine;

N-Acetylgalactosamine;

N6-Acetyl-L-lysine;

Benzylamine;

L-Histidinol;

N-Acetylputrescine;

Agmatine;

Nicotinamide riboside;

(2R,3R)-2-Aminooctadecane-1,3-diol;

3-Dehydroshikimate;

NADPH;

5-Hydroxylysine;

Biopterin;

N-Methyl-D-aspartic acid;

DL-Dopa;

Indole-3-acetamide;

Acetylglycine;

Lumichrome;

Orotidine;

Raffinose;

Methyladenosine;

7-Methylguanosine;

N-Acetylasparagine;

Phosphoribosyl Formamidocarboxamide;

(2R,3R,4S,5R)-2,3,4,5-Tetrahydroxy-6-oxohexyl dihydrogen phosphate;

5'-Phosphoribosyl-N-formylglycinamidine;

5'-Phosphoribosyl-N-Formylglycinamide;

L-a-Phosphatidylcholine;

N-Acetyl-b-glucosaminylamine;

Hydrazine;

Dihydrobiopterin;

Succinyl-Cysteine;

2,5-Dimethylpyrazine;

5-ALPHA-PREGNANE-3-ALPHA,11-BETA,17-ALPHA,21-TETROL-20-ONE 3,21-DIACETATE;

Mono-methyl-adipate;

2-(2-Hydroxy-1H-indol-3-yl)acetic acid;

2-Hydroxyphenethylamine;

Methyl 4-aminobutanoate;

Nicotinamide N-oxide;

D-Alanine;