Study M981
Study name | Li WY 2022 |
Title | Effects of involuntary and voluntary exercise in combination with acousto-optic stimulation on adult neurogenesis in an Alzheimer's mouse model |
Overall design | The aim of this study was to investigate the effect of multifactor intervention, voluntary wheel exercise, and involuntary treadmill running in combination with acousto-optic stimulation, on adult neurogenesis and behavioral phenotypes in the Abeta oligomer mouse model of Alzheimer’s disease. ICR mice were divided into the following 5 groups: (1) control group (sterile injection), (2) Abeta oligomer group (Abeta oligomer injection), (3) Abeta oligomer + involuntary and voluntary running group (Abeta oligomer injection plus running), (4) Abeta oligomer + acousto-optic stimulation group (Abeta oligomer injection plus acousto-optic stimulation), and (5) Abeta oligomer + involuntary and voluntary running + acousto-optic stimulation group (Abeta oligomer injection plus running in combination with acousto-optic stimulation). The mice were injected with sterile saline or Abeta42 oligomer. After a 1-week postoperative recovery, the mice were given treatment administration for 4 weeks. Three serum samples per group were used for metabonomic analysis. |
Study Type | Type1; Type2; |
Data available | Unavailable |
Organism | Mouse; ICR mouse; |
Categories of depression | Animal model; Other animal model; Other animal model; |
Criteria for depression | Forced swimming test, tail suspension test |
Sample size | 15 |
Tissue | Peripheral; Blood; Serum; |
Platform | MS-based; LC-MS: UHPLC (1290 Infinity LC, Agilent Technologies) with quadrupole time-of-fight (AB SCIEX TripleTOF 6600, CA, USA); |
PMID | |
DOI | |
Citation | Li WY, Gao JY, Lin SY, et al. Effects of involuntary and voluntary exercise in combination with acousto-optic stimulation on adult neurogenesis in an Alzheimer's mouse model. Mol Neurobiol. 2022 May;59(5):3254-3279. |
Metabolite | Linoleic acid; Pyroglutamic acid; Myristic acid; Palmitoleic acid; Palmitic acid; L-Glutamic acid; L-Threonine; Arachidonic acid; L-Methionine; L-Glutamine; L-Aspartic acid; Indole-3-propionic acid; Succinic acid; Phenylpyruvic acid; Taurocholic acid; Threonic acid; Phenylacetylglycine; Ascorbic acid; Taurine; Uracil; L-Histidine; Docosahexaenoic acid; Citrulline; L-Malic acid; Methylmalonic acid; Phosphorylcholine; D-Mannose; Heptadecanoic acid; Shikimic acid; Glycerol 3-phosphate; 4-Pyridoxic acid; Valeric acid; D-Tagatose; Propionic acid; p-Cresol; 2-Methyl-3-hydroxybutyric acid; Phenylpropionylglycine; Hexanoylglycine; Sphingosine 1-phosphate; Dihydroxyacetone; Gluconolactone; LysoPC(18:0/0:0); Allose; Dihydrothymine; Gamma-Linolenic acid; 2E-Eicosenoic acid; Juniperic acid; DL-Lactate; Stearidonic acid; Cholesterol sulfate; 20-Hydroxyeicosatetraenoic acid; Adrenic acid; Pectin; Hexadecanedioic acid; D-Arabinono-1,4-lactone; Thromboxane B2; 9-OxoODE; (9R,10S)-(12Z)-9,10-Epoxyoctadecenoic acid; Eicosadienoic acid; Hydroquinone; m-Chlorohippuric acid; L-Gulonolactone; Cyanuric acid; |
