Study M882
Study name | Xu QY 2022 |
Title | Metabolomics changes in brain-gut axis after unpredictable chronic mild stress |
Overall design | In this study, the authors systematically examined the changes of metabolomics after unpredictable chronic mild stress (UCMS)-induced depression-like behaviors in rats and compared the altered metabolites in the hippocampus, jejunum, and serum samples. Sprague-Dawley rats were divided into the following 2 groups (n = 12 in each group): (1) control group, and (2) CUMS group. The CUMS stress procedure lasted for 5 weeks. Hippocampus, jejunum, and serum samples were used for GC-MS-based metabonomic analysis (n = 8/per group). |
Study Type | Type1; |
Data available | Unavailable |
Organism | Rat; Sprague-Dawley rat; |
Categories of depression | Animal model; Chronic mild stress model; Chronic mild stress model; |
Criteria for depression | Sucrose preference test, forced swimming test |
Sample size | 16 |
Tissue | Central; Brain; Hippocampus; Peripheral; Blood; Serum; Peripheral; Gut; Jejunum; |
Platform | MS-based; GC-MS: Thermo Trace 1310-TSQ 8000 gas chromatograph system coupled to a mass spectrometer; |
PMID | |
DOI | |
Citation | Xu Q, Jiang M, Gu S, et al. Metabolomics changes in brain-gut axis after unpredictable chronic mild stress. Psychopharmacology. 2022 Mar;239(3):729-743. |
Metabolite | Gamma-Aminobutyric acid; Phosphoserine; Oleic acid; L-Phenylalanine; L-Tryptophan; L-Valine; L-Proline; L-Glutamic acid; Glycine; L-Serine; L-Threonine; L-Isoleucine; L-Methionine; L-Lactic acid; L-Alanine; L-Asparagine; L-Glutamine; L-Aspartic acid; L-Lysine; L-Tyrosine; 5-Hydroxyindoleacetic acid; L-Arginine; Uridine; L-Cystine; Threonic acid; Urea; Hydroxylamine; Ascorbic acid; Fumaric acid; Ethanolamine; Taurine; Pyruvic acid; D-Xylitol; Gluconic acid; D-Ribose; Beta-Alanine; 5-Methoxytryptamine; Ornithine; 3-Phosphoglyceric acid; Adenosine; L-Carnitine; Sarcosine; Sucrose; Dehydroascorbic acid; Thymine; Benzoic acid; O-Phosphoethanolamine; D-Tagatose; D-Ribulose 5-phosphate; Dihydroxyacetone; Methylphosphate; Glycerol 1-octadecanoate; Iminodiacetic acid; 3'-AMP; Pectin; d-Glucoheptose; Sulfate; Glycerol-1-phosphate; 2-Hydroxycinnamic acid; 4-Hydroxyphenylglycine; Conduritol epoxide; |
