Study M578
Study name | Zhang HF 2019 |
Title | Hippocampal metabolic alteration in rat exhibited susceptibility to prenatal stress |
Overall design | The aim of this study was to explore the potential molecular markers and pathways that link the metabolic to the pathogenesis of depression. The authors monitored changes in hippocampus metabolites during the development of depressive-like behaviors in rats exposed to prenatal stress via UHPLC-Q-TOF/MS approach. Female pregnant Sprague-Dawley rats were divided into the following 2 groups: (1) control group, and (2) restraint stress group (restraint stress during pregnant). One-month old postnatal male rats (control offspring group and restraint stress offspring group, n = 8 in each group) were used for behavioral tests and metabolomics analysis. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Rat; Sprague-Dawley rat; |
Categories of depression | Animal model; Other animal model; Other animal model; |
Criteria for depression | Sucrose preference test, forced swimming test, tail suspension test |
Sample size | 16 |
Tissue | Central; Brain; Hippocampus; |
Platform | MS-based; LC-MS: Agilent 1290 Infinity LC system (Agilent Technologies, Santa-Clara, California, USA) coupled with Agilent 6550 (Agilent Technologies, Santa-Clara, California, USA) and AB SCIEX Triple TOF 6600 System (AB SCIEX, Framingham, MA, USA); |
PMID | |
DOI | |
Citation | Zhang H, He W, Huang Y, et al. Hippocampal metabolic alteration in rat exhibited susceptibility to prenatal stress. J Affect Disord. 2019;259:458-467. |
Metabolite | L-Leucine; L-Glutamic acid; L-Aspartic acid; Choline; Urea; Hypoxanthine; Uracil; Betaine; L-Acetylcarnitine; Betaine aldehyde; L-Carnitine; Stearoylcarnitine; Pipecolic acid; 4-Pyridoxic acid; PC(32:0); O-Phosphoethanolamine; 3-Methylhistidine; Mannose 6-phosphate; gamma-Glutamylglutamic acid; Dimethyl sulfone; Palmitoylethanolamide; N-Acetylaspartylglutamic acid; LysoPE(16:0/0:0); LysoPC(18:0/0:0); N-Acetylneuraminic acid; Beta-D-Fructose 2-phosphate; 20-Hydroxyeicosatetraenoic acid; 1-Aminocyclopropanecarboxylic acid; N6-methyladenosine; Pyridoxal; Maltol; Thioetheramide-PC; |
