Study M512
Study name | Ren Y 2018 |
Title | Chronic stress disturbs metabolome of blood plasma and urine in diabetic rats |
Overall design | This study aimed to investigate the effect of chronic stress on metabolome of plasma and urine in spontaneously diabetic Goto-Kakizaki (GK) rats. The GK rats were subjected to 8 weeks’ chronic unpredictable mild stress (CUMS) to induce depression-like behavior. Metabolome analysis of blood plasma and urine using liquid chromatography mass spectrometry (LC/MS) was performed. Rats were randomly divided into the following 2 groups (n = 12 in each group): (1) control group, (2) CUMS group. The CUMS stress procedure lasted for 8 weeks. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Rat; Goto-Kakizaki rat; |
Categories of depression | Animal model; Chronic mild stress model; Chronic mild stress model; |
Criteria for depression | Not reported |
Sample size | 21 |
Tissue | Peripheral; Blood; Plasma; Peripheral; Urine; Urine; |
Platform | MS-based; LC-MS: Agilent 1290 Infinity LC, 6530 UHD and AccurateMass Q-TOF/MS; |
PMID | |
DOI | |
Citation | Ren Y, Yang CH, Li ZM, et al. Chronic stress disturbs metabolome of blood plasma and urine in diabetic rats. Front Psychiatry. 2018 Oct 23;9:525. |
Metabolite | Glyceric acid; Citric acid; Pyroglutamic acid; Oleic acid; L-Tryptophan; L-Tyrosine; Bilirubin; Cholic acid; Chenodeoxycholic acid; Phytosphingosine; alpha-D-Glucose; L-Malic acid; L-Carnitine; Nicotinic acid; LysoPC(15:0/0:0); Oleamide; LysoPE(18:2); LysoPE(16:0); Alpha-Linolenic acid; Sphingosine; Phenyllactic acid; LysoPE(20:4); LysoPC(22:5); Sphinganine; 2-Methylhippuric acid; |
