Study M464
Study name | Zhou XY 2018 |
Title | Polyunsaturated fatty acids metabolism, purine metabolism and inosine as potential independent diagnostic biomarkers for major depressive disorder in children and adolescents |
Overall design | The aim of this study was to identify biomarkers in plasma samples from depressed children and adolescents and healthy controls based on a non-targeted metabolomics approach. An ultra-high-performance liquid chromatography equipped with quadrupole time-of-flight mass spectrometry-based (UPLC-Q-TOF/MS) non-targeted metabolomics approach was used to compare the plasma metabolic profiles among the drug-naive depressed subjects (drug-naive MDD group, n = 52), drug-treatment depressed subjects (drug-treatment MDD group, n = 32) and matched healthy controls (control group, n = 50) in order to identify biomarkers for depression in children and adolescents. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Pediatric depression; Pediatric depression; |
Criteria for depression | DSM-IV diagnosed MDD, CDRS >= 40 or HAMD-17 >= 17 |
Sample size | 134 |
Tissue | Peripheral; Blood; Plasma; |
Platform | MS-based; LC-MS: Agilent 1290 Infinity LC with AB Triple TOF 6600 (Agilent Technologies, Santa Clara, CA, USA); |
PMID | |
DOI | |
Citation | Zhou X, Liu L, Lan X, et al. Polyunsaturated fatty acids metabolism, purine metabolism and inosine as potential independent diagnostic biomarkers for major depressive disorder in children and adolescents. Mol Psychiatry 2018. |
Metabolite | Linoleic acid; Pyroglutamic acid; Oleic acid; Palmitoleic acid; Palmitic acid; Arachidonic acid; L-Arginine; Azelaic acid; Bilirubin; Chenodeoxycholic acid; Creatinine; Hypoxanthine; Betaine; Creatine; Inosine; Adenosine; Taurochenodesoxycholic acid; PE(18:1/0:0); Alpha-Linolenic acid; Biliverdin; PE(18:2/0:0); PC(18:1/0:0); LysoPS(18:3/0:0); Allose; PC(18:2/24:4); PC(20:5/0:0); Leucyl-Glycine; PC(13:0/22:2); PC(18:0/0:0); PA(18:2/0:0); Chenodeoxycholic acid glycine conjugate; |
