Study M454
Study name | Du HL 2017b |
Title | Metabolic analysis of the antidepressive effects of Yangxinshi Tablet in a vascular depression model in mice |
Overall design | The objective of the study was to identify biomarkers related to vascular depression in hippocampus and explore the antidepressive effects of Yangxinshi Tablet (YXST) on the mouse model. Mice were divided into the following 3 groups: (1) control group, (2) vascular depression model group, and (3) vascular depression model + YXST group (vascular depression model plus Yangxinshi Tablet treatment at the dose of 750 mg/kg). Drugs were administered by gastric gavage for 14 days after surgery. Untargeted metabolomics based on UHPLC-Q-TOF/MS was applied to identify significantly differential biomarkers between the model group and control group. Seven samples in vascular depression model group, eight samples in control group and vascular depression model + YXST group were used for metabonomic analysis. |
Study Type | Type1; Type2; |
Data available | Unavailable |
Organism | Mouse; ICR mouse; |
Categories of depression | Animal model; Other animal model; Other animal model; |
Criteria for depression | Tail suspension test |
Sample size | 23 |
Tissue | Central; Brain; Hippocampus; |
Platform | MS-based; LC-MS: Agilent 1290 Infinity LC system with Agilent 6538 Accurate mass quadrupole time-of-flight mass spectrometer (Agilent, USA); |
PMID | |
DOI | |
Citation | Du H, Zhang H, Zhao Y, et al. Metabolic analysis of the antidepressive effects of Yangxinshi Tablet in a vascular depression model in mice. Biomed Chromatogr 2017. |
Metabolite | Citric acid; Pyroglutamic acid; L-Phenylalanine; L-Tryptophan; L-Valine; L-Leucine; L-Proline; L-Glutamic acid; L-Serine; L-Threonine; L-Glutamine; L-Aspartic acid; Hippuric acid; L-Tyrosine; Phenylpyruvic acid; L-Arginine; Uridine; Pantothenic acid; Hypoxanthine; Xanthine; Taurine; Creatine; L-Histidine; Niacinamide; Inosine; Pyrophosphate; L-Carnitine; Stearoylcarnitine; Indoleacrylic acid; 4-Pyridoxic acid; LysoPE(16:0); Cinnamic acid; L-Palmitoylcarnitine; D-Ribulose 5-phosphate; |
