Study M130
Study name | Bai SJ 2017a |
Title | Insight into the metabolic mechanism of Diterpene Ginkgolides on antidepressant effects for attenuating behavioural deficits compared with venlafaxine |
Overall design | Here, we examined the effects of Diterpene Ginkgolides (DG) and venlafaxine (VLX) in a chronic social defeat stress model of depression. Both DG and VLX attenuated stress-induced social deficits, despair behaviour and exploratory behaviour. To elucidate the metabolic changes underlying the antidepressive effects of DG and VLX, we investigated candidate functional pathways in the prefrontal cortex using a GC-MS-based metabolomics approach. The chronic social defeat stress (CSDS) procedure was performed, then mice were defined as susceptible or resilient to social defeat stress resilient based on the social interaction test. After the CSDS procedure, the susceptible mice were randomly divided into the following three groups: (1) CSDS group (CSDS stress with 0.9% NaCl solution treatment; n = 10), (2) CSDS + DG group (CSDS stress plus Diterpene Ginkgolides Meglumine Injection treatment at the dose of 12.18 mg/kg; n = 11) and (3) CSDS + venlafaxine group (CSDS stress plus venlafaxine treatment at the dose of 16 mg/kg; n = 11). The CSDS stress procedure lasted for 10 days, and drugs were intraperitoneal administered daily for 6 weeks after the model building period. |
Study Type | Type2; |
Data available | Unavailable |
Organism | Mouse; C57BL/6 mouse; |
Categories of depression | Animal model; Social defeat model; Social defeat model; |
Criteria for depression | Sucrose preference test, forced swimming test, tail suspension test, social interaction test |
Sample size | 31 |
Tissue | Central; Brain; Prefrontal cortex; |
Platform | MS-based; GC-MS: Agilent GC system 7890 A equipped with 5975 C mass-selective detector system; |
PMID | |
DOI | |
Citation | Bai S, Zhang X, Chen Z, et al. Insight into the metabolic mechanism of Diterpene Ginkgolides on antidepressant effects for attenuating behavioural deficits compared with venlafaxine. Sci Rep 2017;7(1):9591. |
Metabolite | Gamma-Aminobutyric acid; Pyroglutamic acid; N-Acetyl-L-aspartic acid; L-Phenylalanine; L-Valine; L-Proline; L-Glutamic acid; Arachidonic acid; L-Isoleucine; L-Alanine; L-Asparagine; L-Glutamine; L-Aspartic acid; L-Tyrosine; Hypoxanthine; Fumaric acid; Fructose 6-phosphate; Uracil; D-Ribose; Beta-Alanine; Inosine; Glucose 1-phosphate; Adenosine monophosphate; Inosinic acid; Oxamate; Cytosine; |
