Study M1102
Study name | Yan S 2024 |
Title | Pre-mating nitenpyram exposure in male mice leads to depression-like behavior in offspring by affecting tryptophan metabolism in gut microbiota |
Overall design | The aim of this study was to investigate the effects of pre-mating exposure to nitenpyram in paternal mice on offspring health. ICR mice were divided into the following 2 groups: (1) control group, and (2) nitenpyram group. Mice were gavaged with 0.4 mg/kg nitenpyram solution or pure water every day for 30 days. Then they were made to mate with healthy female mice and produce offspring. The body weights of offspring were recorded weekly, and the offspring were kept for 12 weeks. Tail suspension test were performed in offspring mice on the last day. The results showed that paternal exposure to nitenpyram resulted in increased immobile durations in both male and female offspring. Untargeted metabolomics of cecal contents was used to explore the effects of paternal exposure to nitenpyram on the neurotoxicity of male and female offspring (n = 6 in each group). |
Study Type | Type1; |
Data available | Unavailable |
Organism | Mouse; ICR mouse; |
Categories of depression | Animal model; Other animal model; Other animal model; |
Criteria for depression | Tail suspension test |
Sample size | 24 |
Tissue | Peripheral; Faece; Faece; |
Platform | NMR; NMR: Bruker AV III600 NMR with cryoprobe (Bruker, Billerica, MA, USA); |
PMID | |
DOI | |
Citation | Yan S, Sun W, Tian S, et al. Pre-mating nitenpyram exposure in male mice leads to depression-like behavior in offspring by affecting tryptophan metabolism in gut microbiota. Journal of Environmental Sciences 2024;137,120-130. |
Metabolite | Citric acid; L-Phenylalanine; L-Tryptophan; L-Leucine; L-Glutamic acid; L-Isoleucine; L-Lactic acid; L-Alanine; Hippuric acid; L-Tyrosine; Uridine; Dimethylglycine; Hypoxanthine; Taurine; Betaine; Creatine; alpha-D-Glucose; Phosphorylcholine; |
