Study M1093
Study name | Wang Q 2023 |
Title | Revealing the role of leucine in improving the social avoidance behavior of depression through a combination of untargeted and targeted metabolomics |
Overall design | The aim of this study was to investigate the alterations in the metabolic profile of the chronic social defeat stress (CSDS) model of depression. C57BL/6N mice were divided into the following 2 groups (n = 8 in each group): (1) control group, and (2) CSDS group. The CSDS stress procedure lasted for 2 weeks. Changes in metabolic phenotype of serum and hippocampus were conducted through a combination of untargeted and targeted metabolomics. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Mouse; C57BL/6N mouse; |
Categories of depression | Animal model; Social defeat model; Social defeat model; |
Criteria for depression | Social interaction test, sucrose preference test, forced swimming test |
Sample size | 12 |
Tissue | Peripheral; Blood; Serum; Central; Brain; Hippocampus; |
Platform | MS-based; LC-MS: 1290 Infinity binary pumps Liquid Chromatography System (Agilent Technologies) with 3200 Q Trap (AB Sciex) mass spectrometer; MS-based; LC-MS: not reported; |
PMID | |
DOI | |
Citation | Wang Q, Wu Z, Xiang H, et al. Revealing the role of leucine in improving the social avoidance behavior of depression through a combination of untargeted and targeted metabolomics. Food Funct. 2023 Jun 26. |
Metabolite | Citric acid; L-Phenylalanine; L-Tryptophan; L-Valine; L-Leucine; Arachidonic acid; L-Isoleucine; L-Methionine; L-Arginine; Choline; Hypoxanthine; Uric acid; Xanthine; Betaine; Creatine; L-Acetylcarnitine; Indoleacrylic acid; Oleamide; Spermidine; L-Palmitoylcarnitine; |
