Study M050
Study name | Weckmann K 2014 |
Title | Time-dependent metabolomic profiling of ketamine drug action reveals hippocampal pathway alterations and biomarker candidates |
Overall design | The aim of this study was to carry out a time-dependent hippocampal metabolite profiling analysis of mice treated with ketamine. Mice were divided into 2 groups: (1) control group and (2) ketamine group (ketamine treatment at a single dose of 3 mg/kg). Five hippocampal tissues per treatment (ketamine-treated or vehicle-treated) and per time point (2, 14, 24 and 72 h upon ketamine treatment) were used for targeted metabolomics analysis. |
Study Type | Type3; |
Data available | Unavailable |
Organism | Mouse; C57BL/6 mouse; |
Categories of depression | Healthy individuals; Healthy individuals; Healthy individuals; |
Criteria for depression | Forced swimming test |
Sample size | 40 |
Tissue | Central; Brain; Hippocampus; |
Platform | MS-based; LC-MS: Prominence UFLC high-performance liquid chromatography system (Shimadzu, Columbia, MD, USA) with 5500 QTRAP triple quadrupole mass spectrometer (AB/SCIEX, Framingham, MA, USA); |
PMID | |
DOI | |
Citation | Weckmann K, Labermaier, Asara JM, et al. Time-dependent Metabolomic profiling of ketamine drug action reveals hippocampal pathway alterations and biomarker candidates. Transl Psychiatry 2014;4:e481. |
Metabolite | Glyceric acid; L-Serine; L-Lactic acid; L-Glutamine; Succinic acid; L-Tyrosine; Uridine; Choline; Xanthurenic acid; Fumaric acid; Fructose 6-phosphate; Glucose 6-phosphate; Betaine; Niacinamide; Gluconic acid; Citrulline; Cyclic AMP; Argininosuccinic acid; CDP-Ethanolamine; Hexose-phosphate; 5-Thymidylic acid; dGTP; Adenosine triphosphate; Guanosine triphosphate; Dihydroxyacetone phosphate; SBP; 3-Phosphoglyceric acid; Fructose 1,6-bisphosphate; Glyceraldehyde 3-phosphate; L-Malic acid; L-Acetylcarnitine; Methylmalonic acid; Phenylpropiolic acid; Betaine aldehyde; Maleic acid; Thiamine pyrophosphate; Alpha-ketoisovaleric acid; Glycerophosphocholine; CDP; Carbamoyl phosphate; N-Acetyl-L-alanine; Ureidosuccinic acid; Adenine; Indoleacrylic acid; Putrescine; Glycerol 3-phosphate; Trehalose 6-phosphate; Phosphoenolpyruvic acid; Cytidine; Cytosine; Glucosamine 6-phosphate; Acetyl-CoA; Purine; Uridine 5'-monophosphate; Pipecolic acid; Glutathione; L-Cystathionine; D-Sedoheptulose 7-phosphate; OBP; 5-Methoxytryptophan; Glyoxylic acid; 4-Pyridoxic acid; Thymidine; D-Erythrose 4-phosphate; |
