Study M894
Study name | Luo X 2021 |
Title | Electromagnetic field exposure-induced depression features could be alleviated by heat acclimation based on remodeling the gut microbiota |
Overall design | In this study, a mouse model of intermittent long-term electromagnetic field exposure was used exposure to explore the adverse biological effects of electromagnetic fields. A mouse model of heat acclimation was used to investigate whether heat acclimation play a protective role in disorders of the central nervous system against electromagnetic field exposure. C57BL/6J mice were divided into the following 3 groups (n = 10 in each group): (1) control group, (2) electromagnetic field exposure group, and (3) electromagnetic field exposure + heat acclimation group. The first stage was 4 weeks and the mice in the control group and electromagnetic field exposure group were housed at ambient temperature (28◦C), while the electromagnetic field exposure with heat acclimation group were housed at 35◦C. The second stage was 5 weeks and the mice in the electromagnetic field exposure groups were exposed to electromagnetic field for 4 h a day. The authors reported that electromagnetic field exposure caused depression-like behavior, while heat acclimation alleviated it. Non-targeted liquid chromatography-mass spectrometry metabolomics was performed in serum samples to elucidate the potential mechanism by which heat acclimation alleviates the depression features caused by electromagnetic field exposure. |
Study Type | Type1; Type2; |
Data available | Unavailable |
Organism | Mouse; C57BL/6J mouse; |
Categories of depression | Animal model; Other animal model; Other animal model; |
Criteria for depression | Forced swimming test, tail suspension test |
Sample size | 30 |
Tissue | Peripheral; Blood; Serum; |
Platform | MS-based; LC-MS: Vanquish UHPLC system (Thermo Fisher, Waltham, MA, USA) coupled with an Orbitrap Q Exactive series mass spectrometer (Thermo Fisher, Waltham, MA, USA); |
PMID | |
DOI | |
Citation | Luo X, Huang X, Luo Z, et al. Electromagnetic field exposure-induced depression features could be alleviated by heat acclimation based on remodeling the gut microbiota. Ecotoxicol Environ Saf. 2021 Nov 15;228:112980. |
Metabolite | Citric acid; Pyroglutamic acid; 3-Hydroxybutyric acid; Palmitic acid; Pimelic acid; D-Fructose; L-Kynurenine; Pseudouridine; Phenylacetylglycine; Uric acid; Fumaric acid; L-Histidine; Niacinamide; Gluconic acid; D-Ribose; Inosine; Cholesterol; Adenosine; Guanosine monophosphate; Maleic acid; 1-Methylnicotinamide; L-Carnitine; Sucrose; Quinolinic acid; 3-Hydroxyphenylacetic acid; D-Mannose; Putrescine; Cytidine; Uridine 5'-monophosphate; D-Sedoheptulose 7-phosphate; Thymidine; Acetylphosphate; Phenylacetic acid; Phthalic acid; Butyric acid; Guanosine; Cytidine monophosphate; Guanidoacetic acid; Phosphate; Folic acid; 4-Hydroxycinnamic acid; Oxalacetic acid; Dehydroepiandrosterone; Dodecanoic acid; Ketoleucine; N-Formyl-L-glutamic acid; 4-Oxoproline; N-Formyl-L-methionine; 2-Dehydropantoate; all-trans-Retinoic acid; Formylanthranilic acid; 1-Methylxanthine; Eicosadienoic acid; Quercetin; Lathosterol; Imidazole-4-acetaldehyde; (R)-2,3-Dihydroxy-3-methylvalerate; N-Acetyldemethylphosphinothricin; 3,4-Dihydroxyphenylacetaldehyde; Saccharopine; Se-Methylselenocysteine; Methyl alpha-D-galactopyranoside; 2-Keto-6-aminocaproate; N-Carbamoylputrescine; |
