Study M858

Study name

Zhang YT 2021

Title

[Roles of processing and compatibility in antidepression of Sini Powder: a metabonomics study]

Overall design

The antidepressant mechanism of Sini Powder was investigated in the chronic unpredictable mild stress (CUMS) model of depression by metabonomics. Sprague-Dawley rats were divided into the following 2 groups (n = 6 in each group): (1) control group, and (2) CUMS group. The CUMS stress procedure lasted for 4 weeks. Plasma samples were used for metabonomic analysis.

Study Type

Type1;

Type2;

Data available

Unavailable

Organism

Rat; Sprague-Dawley rat;

Categories of depression

Animal model; Chronic mild stress model; Chronic mild stress model;

Criteria for depression

Sucrose preference test, forced swimming test

Sample size

12

Tissue

Peripheral; Blood; Plasma;

Platform

MS-based; LC-MS: UHPLC (Shimadzu) with Triple TOF 5600 (AB SCIEX);

PMID

34738394

DOI

10.19540/j.cnki.cjcmm.20210319.304

Citation

Zhang YT, Cai H, Duan Y, et al. [Roles of processing and compatibility in antidepression of Sini Powder: a metabonomics study]. Zhongguo Zhong Yao Za Zhi. 2021 Oct;46(19):4993-5004. (Article in Chinese)

Metabolite

L-Valine;

Arachidonic acid;

L-Tyrosine;

Cholic acid;

Carbamoyl phosphate;

L-Carnitine;

6-Phosphogluconic acid;

LysoPC(16:1/0:0);

Sphingosine 1-phosphate;

LysoPC(20:4/0:0);

LysoPC(20:5(5Z,8Z,11Z,14Z,17Z));

Cervonoyl ethanolamide;

LysoPC(20:1(11Z));

5-Phosphoribosylamine;

LysoPE(0:0/20:1(11Z));

Undecanoylcarnitine;