Study M846

Study name

Tian XY 2021

Title

919 syrup alleviates postpartum depression by modulating the structure and metabolism of gut microbes and affecting the function of the hippocampal GABA/glutamate system

Overall design

The aim of this study was to investigate whether 919 syrup could improve the symptoms of postpartum depression by affecting the structure and function of the intestinal flora, thereby altering hippocampal metabolism. Female BALB/c mice were divided into the following 3 groups (n = 9-10 in each group): (1) control group, (2) postpartum depression model group, and (3) postpartum depression model + 919 syrup group (stressor plus venlafaxine treatment at the dose of 25 mg/kg). From postpartum day 2 to postpartum day 23, each mouse in the postpartum depression model was separated from her pups and placed into a separate cage from 13:00 to 16:00 every day. Each mouse was immobilized during this period with a plastic retainer. Saline and 919 syrup (20 mL/kg body weight) were administered once a day via gavage to the postpartum depression model and 919 syrup groups, respectively. Changes in hippocampal metabolism, fecal metabolism, and intestinal microflora of mice were compared.

Study Type

Type1;

Type2;

Data available

Unavailable

Organism

Mouse; BALB/c mouse;

Categories of depression

Animal model; Other animal model; Other animal model;

Criteria for depression

Forced swimming test, tail suspension test

Sample size

28

Tissue

Peripheral; Faece; Faece;

Central; Brain; Hippocampus;

Platform

MS-based; LC-MS: 1290 Infinity LC (Agilent Technologies) with AB Sciex TripleTOF 6600 quadrupole time-of-flight;

PMID

34490139

DOI

10.3389/fcimb.2021.694443

Citation

Tian XY, Xing JW, Zheng QQ, et al. 919 syrup alleviates postpartum depression by modulating the structure and metabolism of gut microbes and affecting the function of the hippocampal GABA/glutamate system. Front Cell Infect Microbiol. 2021 Aug 20;11:694443.

Metabolite

Gamma-Aminobutyric acid;

Linoleic acid;

Stearic acid;

Myristic acid;

L-Phenylalanine;

L-Leucine;

Tyramine;

L-Tyrosine;

L-Arginine;

Pantothenic acid;

Taurocholic acid;

Phytosphingosine;

Creatinine;

Indoxyl sulfate;

Ascorbic acid;

Taurine;

Uracil;

N-Acetyl-L-glutamic acid;

Indolelactic acid;

Niacinamide;

Xanthosine;

Dihydroxyacetone phosphate;

5'-Methylthioadenosine;

L-Malic acid;

L-Acetylcarnitine;

Taurodeoxycholic acid;

Phosphorylcholine;

Oxidized glutathione;

1-Methylnicotinamide;

N-Acetyl-L-alanine;

L-Carnitine;

Adenine;

Sucrose;

N-Acetyl-D-glucosamine;

Heptadecanoic acid;

Dehydroascorbic acid;

5-Aminopentanoic acid;

Cytidine;

Cytosine;

Purine;

Pipecolic acid;

Thymine;

Allantoin;

D-Alanyl-D-alanine;

PC(32:0);

Taurochenodesoxycholic acid;

Guanosine;

N-Acetylleucine;

L-Palmitoylcarnitine;

Alpha-Linolenic acid;

SM(d18:1/18:0);

Sphingosine;

gamma-Glutamylglutamic acid;

Palmitoylethanolamide;

D-Serine;

Kyotorphin;

Dihydrotachysterol;

LysoPE(16:0/0:0);

Urocanic acid;

Leucyl-Glycine;

Glutaral;

Norethindrone Acetate;

Juniperic acid;

Pentadecanoic acid;

Stearidonic acid;

D-Proline;

LysoPC(16:0/0:0);

Thioetheramide-PC;

Cyclohexylamine;

PC(18:0/18:1(9Z));

3'-AMP;

Beta-Guanidinopropionic acid;

6-Keto-prostaglandin F1a;

15-Deoxy-d-12,14-PGJ2;

Hesperetin;

N6-Acetyl-L-lysine;

Erucamide;

7-Ketocholesterol;

D-Mannose 1-phosphate;

DG(18:0/20:4(5Z,8Z,11Z,14Z)/0:0);

LysoPC(18:1(9Z)/0:0);

Acamprosate;

4-Guanidinobutanoic acid;

12-HETE;

Prostaglandin F2a;

1-Palmitoyl-2-oleoyl-phosphatidylglycerol;

Ammelide;

Phenylalanylglycine;

Glycyl-Isoleucine;

Isoleucyl-Lysine;

Valyllysine;

Arginylalanine;

Valylmethionine;

Isoleucyl-Alanine;

Methionyl-Lysine;

Lysylserine;

Isoleucylproline;

Alanylleucine;

3-Palmitoyl-sn-glycerol;

Valylproline;

Histidylisoleucine;

Serylvaline;

Isoleucyl-Arginine;

Glycyl-Arginine;

Valyltyrosine;

Valylvaline;

Prostaglandin I2;

Manumycin A;

Sunitinib;

Bisindolylmaleimide i;

Ergocalciferol;

Linoleoyl ethanolamide;

11-Keto-beta-boswellic acid;

(3-Carboxypropyl)trimethylammonium cation;

Genistein;

D-Maltose;

Senecioic acid;

Apigenin;

Arginylphenylalanine;

Isoleucyl-Aspartate;

Confertifoline;

(9R,10S)-(12Z)-9,10-Epoxyoctadecenoic acid;

13-OxoODE;

D-Methionine (S)-S-oxide;

Oxoadipic acid;

gamma-Linolenic acid;

Prostaglandin A1;

Embelin;

9,10-Epoxystearic acid;

Eicosadienoic acid;

1-O-(cis-9-Octadecenyl)-2-O-acetyl-sn-glycero-3-phosphocholine;

Jasmine lactone;

Vaccenic acid;

Allopurinol riboside;

Lysylleucine;

N6,N6,N6-Trimethyl-L-lysine;

Leucylalanine;

Vitamin D3;