Study M821
Study name | Liu XJ 2021e |
Title | Fecal metabolomics and network pharmacology reveal the correlations between constipation and depression |
Overall design | In this study, fecal metabolomics and network pharmacology were applied to explore the relationships between constipation and depression. The chronic unpredictable mild stress (CUMS) model of depression was constructed. Sprague-Dawley rats were divided into the following 2 groups (n = 6 per group): (1) control group and (2) CUMS group. The CUMS stress procedure lasted for 4 weeks. Fecal samples were used for NMR-based metabonomic analysis. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Rat; Sprague-Dawley rat; |
Categories of depression | Animal model; Chronic mild stress model; Chronic mild stress model; |
Criteria for depression | Sucrose preference test |
Sample size | 12 |
Tissue | Peripheral; Faece; Faece; |
Platform | NMR; NMR: Bruker 600-MHz AVANCE III NMR spectrometer (Bruker Biospin, Rheinstetten, Germany); |
PMID | |
DOI | |
Citation | Liu X, Liu H, Wei F, et al. Fecal metabolomics and network pharmacology reveal the correlations between constipation and depression. J Proteome Res. 2021 Oct 1;20(10):4771-4786. |
Metabolite | L-Valine; L-Leucine; Glycine; L-Threonine; L-Isoleucine; L-Tyrosine; |
